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C75.8 ICD-10-CM Code: Malignant neoplasm with pluriglandular involvement, unspecified

Compare with another codeCheck this code on a claim

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
9 Excludes1
Risk adjustment
CMS-HCC V28: 1 category · CMS-HCC V22 category 12 · RxHCC V08 category 22

Billable · FY2027A valid, specific ICD-10-CM code, reportable for dates of service in FY2027.

What you need to know

Source: CMS/NCHS Official ICD-10-CM tabular notes, quoted. From the CMS/NCHS tabular list for the release in force. A note the category or block publishes applies to this code too; the Instructions section marks which is which.

Excludes1Never report with this code
  • malignant carcinoid tumors (C7A.0-)
  • malignant neoplasm of adrenal gland (C74.-)
  • malignant neoplasm of endocrine pancreas (C25.4)
  • malignant neoplasm of islets of Langerhans (C25.4)

+5 more in Instructions

Most relevant related codes MedCoder-derived

Read off the official notes above and this code’s own position in the tabular list. Which to report is a documentation question; Compare shows the two side by side.

CompareCheck ClaimView Related Codes

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 643 — ENDOCRINE DISORDERS WITH MCC (MDC 10)
  • MS-DRG 644 — ENDOCRINE DISORDERS WITH CC (MDC 10)
  • MS-DRG 645 — ENDOCRINE DISORDERS WITHOUT CC/MCC (MDC 10)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Risk Adjustment (CMS-HCC)

Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.

  • HCC 23 — Prostate, Breast, and Other Cancers and Tumors

Other models: CMS-HCC V22 HCC 12 · RxHCC V08 HCC 22

Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for C75.8 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Trace:FY2027 changesChange historyRelease, file and checksum

Notes without a marker are published on C75.8 itself; “inherited from” names the category or block whose note applies here.

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Source: inherited from C75

Coder workflow for C75.8

MedCoder structured workflow — derived from this code’s own official record

Before you code C75.8

  1. Unspecified does not mean incorrect. When the record gives no greater specificity, C75.8 may be the appropriate code. Check the record for detail that supports a more specific sibling — in this subcategory the siblings differ by the presence or absence of the associated condition. An unspecified code is for records that do not provide the detail a more specific code needs; a query, not an assumption, is the route to specificity (Guidelines I.A.9.b, I.B.18).

    ReviewC75.0, C75.1, C75.2, C75.3, C75.4, C75.5

    See the relationships section · Guide: Other vs unspecified (NEC vs NOS) →

  2. C75.8’s title joins a condition with an associated condition or complication. Confirm each component is documented. Where the classification presumes the link through the “with” convention, only a provider statement that the conditions are unrelated defeats it. A combination code is assigned only when it fully identifies the documented conditions; a required second code for the stage, type or manifestation is still reported when the notes ask for it (Guidelines I.B.9, I.A.15).

    Guide: Combination codes →

  3. Confirm the documented site and behavior (this code’s block classifies malignant neoplasms), whether the site is primary or secondary, and whether the malignancy is current or a personal history: a previously excised malignancy with no further treatment and no evidence of disease is history, not current disease. Verify the site against the Table of Neoplasms. Neoplasm chapter guidelines (Guidelines I.C.2.a, I.C.2.d, I.C.2.m).

    See the Table of Neoplasms entries · Guide: Active cancer vs history of cancer →

  4. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with C75.8. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the record document the detail a more specific sibling code needs?
    Yes → Review the specific siblings in this subcategory.
    No → Continue — C75.8 is appropriate when the documentation goes no further.

    ReviewC75.0, C75.1, C75.2, C75.3, C75.4, C75.5

  2. Does the documentation support a condition named in C75.8’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewC7A.0, C74, C25.4, C56, C62, C37

Consider C75.8. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
Anatomical site
At the most specific level the record states; a site the classification separates cannot be assumed from a procedure or a measurement.
The associated condition or complication
Whether the associated condition the title names is documented; the “with” convention presumes some links, and a provider statement that the conditions are unrelated defeats it (Guidelines I.A.15).
Behavior and current-versus-history status
Malignant, in situ, benign or uncertain; primary or secondary; current disease or personal history (Guidelines I.C.2.m).
Any detail beyond this code’s title
What the record states that a more specific sibling code would capture — or its absence, which itself supports the unspecified code.

Official instructions as workflow

  • Excludes1 — check before selecting C75.8(9 notes)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with C75.8: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareC7A.0, C74, C25.4, C56, C62, C37

    See the official tabular notes · Guidelines I.A.12.a

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: The provider documents the condition in the terms of this code’s title and records no further detail.

Coding question: Is a more specific sibling code supportable?

Path: Review the specific siblings in this subcategory and what each requires the record to state.

Reason: A more specific code needs documentation of the distinguishing element; without it the unspecified code is appropriate, and a provider query is the route to specificity (Guidelines I.A.9.b, I.B.18).

ReviewC75.0, C75.1, C75.2, C75.3, C75.4, C75.5

Documentation: Both the condition C75.8 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewC7A.0, C74, C25.4, C56, C62, C37

Documentation: Only one of the components this code’s title joins is documented.

Coding question: Is C75.8 supported?

Path: Review the code for the documented component on its own.

Reason: A combination code is assigned only when it fully identifies the documented conditions; otherwise the documented component takes its own code (Guidelines I.B.9).

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Don’t confuse C75.8 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of C75.8 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

  • C7A.0— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of malignant carcinoid tumors moves the case to C7A.0; the two are not reported together unless documented as unrelated.

    Full comparison: C75.8 vs C7A.0 →

  • C74— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of malignant neoplasm of adrenal gland moves the case to C74; the two are not reported together unless documented as unrelated.

    Full comparison: C75.8 vs C74 →

  • C25.4— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of malignant neoplasm of endocrine pancreas moves the case to C25.4; the two are not reported together unless documented as unrelated.

    Full comparison: C75.8 vs C25.4 →

  • C56— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of malignant neoplasm of ovary moves the case to C56; the two are not reported together unless documented as unrelated.

    Full comparison: C75.8 vs C56 →

  • C62— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of malignant neoplasm of testis moves the case to C62; the two are not reported together unless documented as unrelated.

    Full comparison: C75.8 vs C62 →

  • C37— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of malignant neoplasm of thymus moves the case to C37; the two are not reported together unless documented as unrelated.

    Full comparison: C75.8 vs C37 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Coding context

Guidelines, coding notes, decision aids, relationships (with MS-DRG and CCSR classification), hierarchy, HCC, coverage and the context map: what a coder reaches for after the core. Each section names whether it is official source data, a MedCoder-derived relationship or MedCoder editorial.

Code Overview

Malignant neoplasm with pluriglandular involvement, unspecified is a billable ICD-10-CM diagnosis code (C75.8).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Verify Before Coding

  • CC as a secondary diagnosis (FY2027). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder-derived relationships — computed from published CMS and AHRQ datasets

Other codes that name C75.8 or its code family, from the CMS Table of Neoplasms.

Referenced by 5 Same-site neoplasm codes: C79.89 — Secondary malignant neoplasm of other specified sitesCompare C75.8 vs C79.89 →, D09.3 — Carcinoma in situ of thyroid and other endocrine glandsCompare C75.8 vs D09.3 →, D35.7 — Benign neoplasm of other specified endocrine glandsCompare C75.8 vs D35.7 →, D44.9 — Neoplasm of uncertain behavior of unspecified endocrine glandCompare C75.8 vs D44.9 →, D49.7 — Neoplasm of unspecified behavior of endocrine glands and other parts of nervous systemCompare C75.8 vs D49.7 →.

These codes represent related neoplasm behaviors affecting the same anatomic site.

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 17 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 3 MS-DRGs: DRG 643 (MDC 10), DRG 644 (MDC 10), DRG 645 (MDC 10).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):NEO056 — Endocrine system cancers - all other types (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

C74.00 — Malignant neoplasm of cortex of unspecified adrenal gland, C74.01 — Malignant neoplasm of cortex of right adrenal gland, C74.02 — Malignant neoplasm of cortex of left adrenal gland, C74.10 — Malignant neoplasm of medulla of unspecified adrenal gland, C74.11 — Malignant neoplasm of medulla of right adrenal gland, C74.12 — Malignant neoplasm of medulla of left adrenal gland, C74.90 — Malignant neoplasm of unspecified part of unspecified adrenal gland, C74.91 — Malignant neoplasm of unspecified part of right adrenal gland, C74.92 — Malignant neoplasm of unspecified part of left adrenal gland, C75.0 — Malignant neoplasm of parathyroid gland, C75.1 — Malignant neoplasm of pituitary gland, C75.2 — Malignant neoplasm of craniopharyngeal duct, C75.3 — Malignant neoplasm of pineal gland, C75.4 — Malignant neoplasm of carotid body, C75.5 — Malignant neoplasm of aortic body and other paraganglia, C75.9 — Malignant neoplasm of endocrine gland, unspecified

Same CMS-HCC risk category (V28)

CMS maps these diagnoses to the same Hierarchical Condition Category (Prostate, Breast, and Other Cancers and Tumors) for risk-adjusted payment.

C69.80 — Malignant neoplasm of overlapping sites of unspecified eye and adnexa, C69.81 — Malignant neoplasm of overlapping sites of right eye and adnexa, C69.82 — Malignant neoplasm of overlapping sites of left eye and adnexa, C69.90 — Malignant neoplasm of unspecified site of unspecified eye, C69.91 — Malignant neoplasm of unspecified site of right eye, C69.92 — Malignant neoplasm of unspecified site of left eye, C73 — Malignant neoplasm of thyroid gland, C75.0 — Malignant neoplasm of parathyroid gland, C75.4 — Malignant neoplasm of carotid body, C75.5 — Malignant neoplasm of aortic body and other paraganglia, C75.9 — Malignant neoplasm of endocrine gland, unspecified, C76.0 — Malignant neoplasm of head, face and neck, C76.1 — Malignant neoplasm of thorax, C76.2 — Malignant neoplasm of abdomen, C76.3 — Malignant neoplasm of pelvis, C76.40 — Malignant neoplasm of unspecified upper limb, C76.41 — Malignant neoplasm of right upper limb, C76.42 — Malignant neoplasm of left upper limb, C76.50 — Malignant neoplasm of unspecified lower limb, C76.51 — Malignant neoplasm of right lower limb, +213 more

Related risk categories

These categories interact through CMS's HCC hierarchy — one can suppress the other's risk-adjustment weight when both are present on a claim.

Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic, Cancer Metastatic to Bone, Other and Unspecified Metastatic Cancer; Acute Leukemia Except Myeloid, Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers, Lung and Other Severe Cancers, Lymphoma and Other Cancers, Bladder, Colorectal, and Other Cancers

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Endocrine system cancers - all other types).

C74.10 — Malignant neoplasm of medulla of unspecified adrenal gland, C74.11 — Malignant neoplasm of medulla of right adrenal gland, C74.12 — Malignant neoplasm of medulla of left adrenal gland, C74.90 — Malignant neoplasm of unspecified part of unspecified adrenal gland, C74.91 — Malignant neoplasm of unspecified part of right adrenal gland, C74.92 — Malignant neoplasm of unspecified part of left adrenal gland, C75.2 — Malignant neoplasm of craniopharyngeal duct, C75.3 — Malignant neoplasm of pineal gland, C75.4 — Malignant neoplasm of carotid body, C75.5 — Malignant neoplasm of aortic body and other paraganglia, C75.9 — Malignant neoplasm of endocrine gland, unspecified

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Iron Panel, Thyroid Stimulating Hormone (TSH)

Contextual Map

Every relationship of C75.8 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

Same site

Referenced by Same-site neoplasm codes

Clinical classification (CCSR)

Risk adjustment (CMS-HCC)

  • HCC 23 — Prostate, Breast, and Other Cancers and Tumors [CMS-HCC]— CMS-HCC V28 · 2026

MS-DRG Grouper

  • CC — Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (CC).”— CMS MS-DRG Definitions Manual (Appendix C) · FY2027
  • DRG 643 — ENDOCRINE DISORDERS WITH MCC[MS-DRG]: “ENDOCRINE DISORDERS WITH MCC (MDC 10)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
  • DRG 644 — ENDOCRINE DISORDERS WITH CC[MS-DRG]: “ENDOCRINE DISORDERS WITH CC (MDC 10)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
  • DRG 645 — ENDOCRINE DISORDERS WITHOUT CC/MCC[MS-DRG]: “ENDOCRINE DISORDERS WITHOUT CC/MCC (MDC 10)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2027

MDC crossing

  • MDC 10 — Endocrine, Nutritional and Metabolic Diseases and Disorders[MDC crossing]: “Endocrine, Nutritional and Metabolic Diseases and Disorders — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 5,013 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2027

Neoplasm sites

  • Neoplasm, neoplastic, endocrine gland NEC, pluriglandular — Neoplasm, neoplastic, endocrine gland NEC, pluriglandular — Malignant, Primary [Neoplasm table]: “Neoplasm, neoplastic, endocrine gland NEC, pluriglandular (Malignant, Primary)”— CMS Table of Neoplasms · icd10cm-fy2027
  • Neoplasm, neoplastic, pluriendocrine — Neoplasm, neoplastic, pluriendocrine — Malignant, Primary [Neoplasm table]: “Neoplasm, neoplastic, pluriendocrine (Malignant, Primary)”— CMS Table of Neoplasms · icd10cm-fy2027

Nearest codes

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Reference

Index terms and tables, published questions and FAQ, every source behind this page with its release and checksum, the date-of-service check and the complete change history.

Neoplasm Table Sites (2)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Anatomical sites from the official ICD-10-CM Table of Neoplasms that map to this code, with the matching behavior column.

  • Neoplasm, neoplastic, endocrine gland NEC, pluriglandular — Malignant, Primary
  • Neoplasm, neoplastic, pluriendocrine — Malignant, Primary

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Risk adjustment Official source data
2026 Mid-Year Final ICD-10 Mappings + Model Software (cms.gov/files/zip/2026-midyear-final-icd-10-mappings.zip, 2026-midyear-final-model-software.zip) — CMS-HCC V28, PY2026 mid-year final release Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder-derived relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder editorial explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 20, 2026 · All releases and sources

Labels on this page: Official source data · MedCoder-derived relationship · MedCoder editorial explanation. How to read the labels · All data sources and release dates · CMS coding rules

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "C75.8 — Malignant neoplasm with pluriglandular involvement, unspecified." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/c75.8-malignant-neoplasm-with-pluriglandular-involvement-unspecified

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Malignant neoplasm with pluriglandular involvement, unspecified

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027, and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to C75.8 in its code family, with their registry titles.

View all codes in the C75 family