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D57.43 ICD-10-CM Code: Sickle-cell thalassemia beta zero with crisis

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Billing Status: NO. This is a non-billable ICD-10-CM code: report a more specific billable code beneath it.

Coding at a Glance

Tabular directives
2 inclusion terms · 1 Excludes1 · 1 use-additional code

Not billable · FY2027A non-billable heading in the tabular list: report a more specific code beneath it.

What you need to know

Source: CMS/NCHS Official ICD-10-CM tabular notes, quoted. From the CMS/NCHS tabular list for the release in force. A note the category or block publishes applies to this code too; the Instructions section marks which is which.

Use additional codeReport with this code when documented
  • code for any associated fever (R50.81)
Excludes1Never report with this code
  • other hemoglobinopathies (D58.-)
IncludesWhat this code covers
  • HbS-beta zero with crisis
  • Sickle-cell beta zero with crisis

Most relevant related codes MedCoder-derived

Read off the official notes above and this code’s own position in the tabular list. Which to report is a documentation question; Compare shows the two side by side.

CompareCheck ClaimView Related Codes

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for D57.43 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Trace:FY2027 changesChange historyRelease, file and checksum

Notes without a marker are published on D57.43 itself; “inherited from” names the category or block whose note applies here.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • HbS-beta zero with crisis
  • Sickle-cell beta zero with crisis

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Source: inherited from D57

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code for any associated fever (R50.81)

Source: inherited from D57

Coder workflow for D57.43

MedCoder structured workflow — derived from this code’s own official record

Before you code D57.43

  1. D57.43 is not reportable as written. Select the more specific code beneath it that the documentation supports. Codes are reported to the highest level of specificity the classification provides (Guidelines I.B.2).

    ReviewD57.431, D57.432, D57.433, D57.434, D57.438, D57.439

    See the relationships section · Guide: How to choose an ICD-10-CM code →

  2. D57.43’s title joins a condition with an associated condition or complication. Confirm each component is documented. Where the classification presumes the link through the “with” convention, only a provider statement that the conditions are unrelated defeats it. A combination code is assigned only when it fully identifies the documented conditions; a required second code for the stage, type or manifestation is still reported when the notes ask for it (Guidelines I.B.9, I.A.15).

    Guide: Combination codes →

  3. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with D57.43. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the documentation support one of the more specific codes beneath D57.43?
    Yes → Select that code and continue the checks below on its own page.
    No → D57.43 cannot be reported as written; query for the specificity its subcategory needs.

    ReviewD57.431, D57.432, D57.433, D57.434, D57.438, D57.439

  2. Does the documentation support a condition named in D57.43’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewD58

Consider D57.43. Then work the Use Additional Code note, and confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
The associated condition or complication
Whether the associated condition the title names is documented; the “with” convention presumes some links, and a provider statement that the conditions are unrelated defeats it (Guidelines I.A.15).
The conditions the Use Additional Code note names
Reported with this code when documented; a conditional instruction (“if applicable”, “if known”) applies only when the record supports it.

Official instructions as workflow

  • Excludes1 — check before selecting D57.43(1 note)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with D57.43: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareD58

    See the official tabular notes · Guidelines I.A.12.a

  • Use Additional Code — after identifying D57.43(1 note)

    Coding workflow: Check whether the documentation supports the additional code(s) the note names, and report them with D57.43 when it does. Where the instruction is conditional (“if applicable”, “if known”), it applies only when the record documents the condition.

    ReviewR50.81

    See the official tabular notes · Guidelines I.A.13

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: Both the condition D57.43 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewD58

Documentation: Only one of the components this code’s title joins is documented.

Coding question: Is D57.43 supported?

Path: Review the code for the documented component on its own.

Reason: A combination code is assigned only when it fully identifies the documented conditions; otherwise the documented component takes its own code (Guidelines I.B.9).

Documentation: A condition the Use Additional Code note names is documented.

Coding question: Is a second code reported with D57.43?

Path: Review the Use Additional Code note and the code it names.

Reason: The additional code is reported when the record documents the condition; a conditional instruction applies only when its condition is met (Guidelines I.A.13).

ReviewR50.81

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Don’t confuse D57.43 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of D57.43 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

  • D58— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of other hemoglobinopathies moves the case to D58; the two are not reported together unless documented as unrelated.

    Full comparison: D57.43 vs D58 →

  • D57.41— Specificity relationship (Review)

    Overlapping diagnoses in the same category.

    Overlapping codes in the same category — the documentation decides which is the more specific fit.

    What moves you there: A record that documents no more than “Sickle-cell thalassemia, unspecified, with crisis” takes D57.41; specificity in the record moves it back here.

    Full comparison: D57.43 vs D57.41 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Coding context

Guidelines, coding notes, decision aids, relationships (with MS-DRG and CCSR classification), hierarchy, HCC, coverage and the context map: what a coder reaches for after the core. Each section names whether it is official source data, a MedCoder-derived relationship or MedCoder editorial.

Code Overview

Sickle-cell thalassemia beta zero with crisis is a non-billable ICD-10-CM category code (D57.43). A more specific billable subcode must be selected for claims submission.

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Verify Before Coding

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder-derived relationships — computed from published CMS and AHRQ datasets

Other codes that name D57.43 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 18 Excludes1 notes across 3 chapters: D56 — Thalassemia (via D57.4.-), D56.1 — Beta thalassemia (via D57.4.-), D56.5 — Hemoglobin E-beta thalassemia (via D57.4.-), D56.8 — Other thalassemias (via D57.-), P50 — Newborn affected by intrauterine (fetal) blood loss (via D57.-), P50-P61 — Hemorrhagic and hematological disorders of newborn (P50-P61) (via D57.-), P51 — Umbilical hemorrhage of newborn (via D57.-), P52 — Intracranial nontraumatic hemorrhage of newborn (via D57.-), P53 — Hemorrhagic disease of newborn (via D57.-), P54 — Other neonatal hemorrhages (via D57.-), P55 — Hemolytic disease of newborn (via D57.-), P56 — Hydrops fetalis due to hemolytic disease (via D57.-), P57 — Kernicterus (via D57.-), P58 — Neonatal jaundice due to other excessive hemolysis (via D57.-), P59 — Neonatal jaundice from other and unspecified causes (via D57.-), P60 — Disseminated intravascular coagulation of newborn (via D57.-), P61 — Other perinatal hematological disorders (via D57.-), R71 — Abnormality of red blood cells (via D57.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 27 Code First instructions across 6 chapters: H36 — Retinal disorders in diseases classified elsewhere (via D57.-), I21.A1 — Myocardial infarction type 2 (via D57.-), M14.8 — Arthropathies in other specified diseases classified elsewhere (via D57.-), M90.5 — Osteonecrosis in diseases classified elsewhere (via D57.-), N08 — Glomerular disorders in diseases classified elsewhere (via D57.-), R50.81 — Fever presenting with conditions classified elsewhere (via D57.-), T36 — Poisoning by, adverse effect of and underdosing of systemic antibiotics (via D57.-), T36-T39 — Antibiotics & Anti-infectives (T36-T39) (via D57.-), T36-T50 — Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances (T36-T50) (via D57.-), T37 — Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics (via D57.-), T38 — Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified (via D57.-), T39 — Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics (via D57.-), T40 — Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens] (via D57.-), T40-T41 — Analgesics & Antipyretics (T40-T41) (via D57.-), T41 — Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gases (via D57.-), T42 — Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs (via D57.-), T42-T43 — Anticonvulsants & Psychotropics (T42-T43) (via D57.-), T43 — Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified (via D57.-), T44 — Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system (via D57.-), T44-T46 — Cardiovascular & Gastrointestinal (T44-T46) (via D57.-), +7 more.

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

Referenced by 1 Code Also instruction: Z71.87 — Encounter for pediatric-to-adult transition counseling (via D57.-).

These codes suggest coding this condition alongside when both are present.

Related Codes

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Arthropathy”; these codes share that main term but sit in a different category of the Tabular List.

A04.6 — Enteritis due to Yersinia enterocolitica (postinfectious NEC, in, enteritis due to Yersinia enterocolitica), A50.55 — Late congenital syphilitic arthropathy (in, syphilis, congenital), A52.16 — Charcôt's arthropathy (tabetic) (tabetic), A52.77 — Syphilis of bone and joint (in, syphilis), B19.9 — Unspecified viral hepatitis without hepatic coma (in, viral hepatitis NEC), B99 — Other and unspecified infectious diseases (postinfectious NEC), C90.0 — Multiple myeloma (in, multiple myeloma), C95.9 — Leukemia, unspecified (in, leukemia NEC), C96.A — Histiocytic sarcoma (in, malignant histiocytosis), D49.9 — Neoplasm of unspecified behavior of unspecified site (in, neoplastic disease NOS), D58.2 — Other hemoglobinopathies (in, hemoglobinopathy NEC), D66 — Hereditary factor VIII deficiency (hemophilic NEC), D69.0 — Allergic purpura (in, Henoch-Schönlein purpura), D75.9 — Disease of blood and blood-forming organs, unspecified (in, blood disorder NOS), D86.86 — Sarcoid arthropathy (in, sarcoidosis), E03.9 — Hypothyroidism, unspecified (in, hypothyroidism), E05.90 — Thyrotoxicosis, unspecified without thyrotoxic crisis or storm (in, thyrotoxicosis), E21.3 — Hyperparathyroidism, unspecified (hemophilic NEC, in, hyperparathyroidism NEC), E22.0 — Acromegaly and pituitary gigantism (in, acromegaly), E34.9 — Endocrine disorder, unspecified (in, endocrine disease NOS), +112 more

Contextual Map

Every relationship of D57.43 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run D57.43 with these 17 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes (18)

Referenced by Code First instructions (27)

Referenced by Code Also instructions

Nearest codes (40)

Change history

Reference

Index terms and tables, published questions and FAQ, every source behind this page with its release and checksum, the date-of-service check and the complete change history.

Common coding questions

MedCoder editorial

Can D57.43 be billed directly?

No. D57.43 (Sickle-cell thalassemia beta zero with crisis) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder-derived relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder editorial explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 20, 2026 · All releases and sources

Labels on this page: Official source data · MedCoder-derived relationship · MedCoder editorial explanation. How to read the labels · All data sources and release dates · CMS coding rules

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "D57.43 — Sickle-cell thalassemia beta zero with crisis." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/d57.43-sickle-cell-thalassemia-beta-zero-with-crisis

Change history

  • FY2021 — October 1, 2020
    Added to the code set
    Sickle-cell thalassemia beta zero with crisis
    FY2021 changes

Nearest Codes in This Family

Official ICD-10-CM classifications closest to D57.43 in its code family, with their registry titles.

View all codes in the D57 family