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D59.13 ICD-10-CM Code: Mixed type autoimmune hemolytic anemia

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0, Appendix B.

  • MS-DRG 808 — MAJOR HEMATOLOGICAL AND IMMUNOLOGICAL DIAGNOSES EXCEPT SICKLE CELL CRISIS AND COAGULATION DISORDERS WITH MCC (MDC 16)
  • MS-DRG 809 — MAJOR HEMATOLOGICAL AND IMMUNOLOGICAL DIAGNOSES EXCEPT SICKLE CELL CRISIS AND COAGULATION DISORDERS WITH CC (MDC 16)
  • MS-DRG 810 — MAJOR HEMATOLOGICAL AND IMMUNOLOGICAL DIAGNOSES EXCEPT SICKLE CELL CRISIS AND COAGULATION DISORDERS WITHOUT CC/MCC (MDC 16)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Risk Adjustment (CMS-HCC)

Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.

  • HCC 109 — Acquired Hemolytic, Aplastic, and Sideroblastic Anemias

Other models: CMS-HCC V22 HCC 46 · RxHCC V08 HCC 96

Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.

Official Registry Overview & Definition

Mixed type autoimmune hemolytic anemia is a billable ICD-10-CM diagnosis code (D59.13).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for D59.13 in the official ICD-10-CM tabular list.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Mixed type autoimmune hemolytic disease
  • Mixed type, cold and warm, (primary) (secondary) (symptomatic) autoimmune hemolytic anemia

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Indexed Clinical Terms (7)

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.

  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, autoimmune, mixed
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, mixed type (primary) (secondary) (symptomatic)
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, primary, autoimmune, mixed type
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, secondary, autoimmune, mixed type
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, symptomatic, autoimmune, mixed type
  • Disease, diseased, autoimmune NOS (systemic), hemolytic, mixed type (primary) (secondary) (symptomatic)
  • Disease, diseased, hemolytic (newborn), autoimmune, mixed type (primary) (secondary) (symptomatic)

Frequently Compared Codes

The official Excludes notes on D59.13 name these codes. Each comparison page covers when the two can — or must not — be reported together.

Change history

  • FY2021 — 2020-10-01
    Added to the code set
    Mixed type autoimmune hemolytic anemia
    FY2021 changes

Verify Before Coding

  • CC as a secondary diagnosis (FY2026). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim.

Relationships & Classification

Potential MS-DRG Relationships (FY2026)

CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 16 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 3 MS-DRGs: DRG 808 (MDC 16), DRG 809 (MDC 16), DRG 810 (MDC 16).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):BLD002 — Hemolytic anemia (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Contextual Map

Every relationship of D59.13 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

  • D50-D89 — Chapter 3: Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) (D50-D89) [Hierarchy]

Clinical classification (CCSR)

  • BLD002 — Hemolytic anemia [CCSR]

Risk adjustment (CMS-HCC)

  • HCC 109 — Acquired Hemolytic, Aplastic, and Sideroblastic Anemias [CMS-HCC]

Potential MS-DRG

  • CC — Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (CC).”
  • DRG 808 — MAJOR HEMATOLOGICAL AND IMMUNOLOGICAL DIAGNOSES EXCEPT SICKLE CELL CRISIS AND COAGULATION DISORDERS WITH MCC [MS-DRG]: “MAJOR HEMATOLOGICAL AND IMMUNOLOGICAL DIAGNOSES EXCEPT SICKLE CELL CRISIS AND COAGULATION DISORDERS WITH MCC (MDC 16)”
  • DRG 809 — MAJOR HEMATOLOGICAL AND IMMUNOLOGICAL DIAGNOSES EXCEPT SICKLE CELL CRISIS AND COAGULATION DISORDERS WITH CC [MS-DRG]: “MAJOR HEMATOLOGICAL AND IMMUNOLOGICAL DIAGNOSES EXCEPT SICKLE CELL CRISIS AND COAGULATION DISORDERS WITH CC (MDC 16)”
  • DRG 810 — MAJOR HEMATOLOGICAL AND IMMUNOLOGICAL DIAGNOSES EXCEPT SICKLE CELL CRISIS AND COAGULATION DISORDERS WITHOUT CC/MCC [MS-DRG]: “MAJOR HEMATOLOGICAL AND IMMUNOLOGICAL DIAGNOSES EXCEPT SICKLE CELL CRISIS AND COAGULATION DISORDERS WITHOUT CC/MCC (MDC 16)”

MDC crossing · procedures (1614)

  • MDC 16 — Diseases and Disorders of Blood, Blood Forming Organs and Immunologic Disorders [MDC crossing]: “Diseases and Disorders of Blood, Blood Forming Organs and Immunologic Disorders — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs.”
  • 02HV02Z — Insertion of Monitoring Device into Superior Vena Cava, Open Approach [Same-MDC procedure]: “Insertion of Monitoring Device into Superior Vena Cava, Open Approach — grouped in MDC 16, the procedure side of this code's crossing.” · check together
  • 02HV0DZ — Insertion of Intraluminal Device into Superior Vena Cava, Open Approach [Same-MDC procedure]: “Insertion of Intraluminal Device into Superior Vena Cava, Open Approach — grouped in MDC 16, the procedure side of this code's crossing.” · check together
  • 02HV3DZ — Insertion of Intraluminal Device into Superior Vena Cava, Percutaneous Approach [Same-MDC procedure]: “Insertion of Intraluminal Device into Superior Vena Cava, Percutaneous Approach — grouped in MDC 16, the procedure side of this code's crossing.” · check together
  • 02HV42Z — Insertion of Monitoring Device into Superior Vena Cava, Percutaneous Endoscopic Approach [Same-MDC procedure]: “Insertion of Monitoring Device into Superior Vena Cava, Percutaneous Endoscopic Approach — grouped in MDC 16, the procedure side of this code's crossing.” · check together
  • 02HV4DZ — Insertion of Intraluminal Device into Superior Vena Cava, Percutaneous Endoscopic Approach [Same-MDC procedure]: “Insertion of Intraluminal Device into Superior Vena Cava, Percutaneous Endoscopic Approach — grouped in MDC 16, the procedure side of this code's crossing.” · check together
  • and 1609 more

Index entries

  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, autoimmune, mixed[Index term]
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, mixed type (primary) (secondary) (symptomatic)[Index term]
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, primary, autoimmune, mixed type[Index term]
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, secondary, autoimmune, mixed type[Index term]
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, symptomatic, autoimmune, mixed type[Index term]
  • Disease, diseased, autoimmune NOS (systemic), hemolytic, mixed type (primary) (secondary) (symptomatic)[Index term]
  • Disease, diseased, hemolytic (newborn), autoimmune, mixed type (primary) (secondary) (symptomatic)[Index term]

Nearest codes (18)

  • D59 — Acquired hemolytic anemia [Sibling]
  • D59.0 — Drug-induced autoimmune hemolytic anemia [Sibling]
  • D59.1 — Other autoimmune hemolytic anemias [Sibling]
  • D59.10 — Autoimmune hemolytic anemia, unspecified [Sibling]
  • D59.11 — Warm autoimmune hemolytic anemia [Sibling]
  • D59.12 — Cold autoimmune hemolytic anemia [Sibling]
  • D59.19 — Other autoimmune hemolytic anemia [Sibling]
  • D59.2 — Drug-induced nonautoimmune hemolytic anemia [Sibling]
  • and 10 more

Change history

  • FY2021 — Added to the code set [Change history]

Nearest Codes in This Family

Official ICD-10-CM classifications closest to D59.13 in its code family, with their registry titles.

  • D59.0 — Drug-induced autoimmune hemolytic anemia
  • D59.1 — Other autoimmune hemolytic anemias
  • D59.10 — Autoimmune hemolytic anemia, unspecified
  • D59.11 — Warm autoimmune hemolytic anemia
  • D59.12 — Cold autoimmune hemolytic anemia
  • D59.19 — Other autoimmune hemolytic anemia
  • D59.2 — Drug-induced nonautoimmune hemolytic anemia
  • D59.3 — Hemolytic-uremic syndrome
  • D59.30 — Hemolytic-uremic syndrome, unspecified
  • D59.31 — Infection-associated hemolytic-uremic syndrome

View all codes in the D59 family