I95.2 ICD-10-CM Code: Hypotension due to drugs

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for I95.2 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on I95.2 itself; “inherited from” names the category or block whose note applies here.

Coder workflow for I95.2

MedCoder structured workflow — derived from this code’s own official record

Before you code I95.2

1. I95.2’s title joins a condition with an associated condition or complication. Confirm each component is documented. Where the classification presumes the link through the “with” convention, only a provider statement that the conditions are unrelated defeats it. A combination code is assigned only when it fully identifies the documented conditions; a required second code for the stage, type or manifestation is still reported when the notes ask for it (Guidelines I.B.9, I.A.15).

   Guide: Combination codes →

2. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with I95.2. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

   See the official tabular notes

Choose the right path

1. Does the documentation support a condition named in I95.2’s Excludes1 note?
   Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
   No → Continue.

   ReviewR57.9, O26.5, R03.1

Consider I95.2. Then work the Use Additional Code note, and confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement

Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

The associated condition or complication

Whether the associated condition the title names is documented; the “with” convention presumes some links, and a provider statement that the conditions are unrelated defeats it (Guidelines I.A.15).

The conditions the Use Additional Code note names

Reported with this code when documented; a conditional instruction (“if applicable”, “if known”) applies only when the record supports it.

Official instructions as workflow

• Excludes1 — check before selecting I95.2(3 notes)

  Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with I95.2: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

  CompareR57.9, O26.5, R03.1

  See the official tabular notes · Guidelines I.A.12.a

• Use Additional Code — after identifying I95.2(1 note)

  Coding workflow: Check whether the documentation supports the additional code(s) the note names, and report them with I95.2 when it does. Where the instruction is conditional (“if applicable”, “if known”), it applies only when the record documents the condition.

  See the official tabular notes · Guidelines I.A.13

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Indexed Clinical Terms (3)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

• Crisis, nitritoid
• Hypotension (arterial) (constitutional), drug-induced
• Hypotension (arterial) (constitutional), orthostatic (chronic), due to drugs

Don’t confuse I95.2 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of I95.2 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

• R57.9— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of cardiovascular collapse moves the case to R57.9; the two are not reported together unless documented as unrelated.

  Full comparison: I95.2 vs R57.9 →

• O26.5— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of maternal hypotension syndrome moves the case to O26.5; the two are not reported together unless documented as unrelated.

  Full comparison: I95.2 vs O26.5 →

• R03.1— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of nonspecific low blood pressure reading NOS moves the case to R03.1; the two are not reported together unless documented as unrelated.

  Full comparison: I95.2 vs R03.1 →

• I95.9— Specificity relationship (Review)

  Overlapping diagnoses in the same category.

  Overlapping codes in the same category — the documentation decides which is the more specific fit.

  What moves you there: A record that documents no more than “Hypotension, unspecified” takes I95.9; specificity in the record moves it back here.

  Full comparison: I95.2 vs I95.9 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Verify Before Coding

• No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name I95.2 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 2 Excludes1 notes across 2 chapters: I95.1 — Orthostatic hypotension, R03.1 — Nonspecific low blood-pressure reading (via I95.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 1 MS-DRG: DRG 312 (MDC 05).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):INJ030 — Drug induced or toxic related condition (default); CIR031 — Hypotension.

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical categories (Drug induced or toxic related condition, Hypotension).

H40.63X3 — Glaucoma secondary to drugs, bilateral, severe stage, H40.63X4 — Glaucoma secondary to drugs, bilateral, indeterminate stage, H46.3 — Toxic optic neuropathy, H91.01 — Ototoxic hearing loss, right ear, H91.02 — Ototoxic hearing loss, left ear, H91.03 — Ototoxic hearing loss, bilateral, H91.09 — Ototoxic hearing loss, unspecified ear, I42.7 — Cardiomyopathy due to drug and external agent, I95.0 — Idiopathic hypotension, I95.1 — Orthostatic hypotension, I95.3 — Hypotension of hemodialysis, I95.81 — Postprocedural hypotension, I95.89 — Other hypotension, I95.9 — Hypotension, unspecified, J70.2 — Acute drug-induced interstitial lung disorders, J70.3 — Chronic drug-induced interstitial lung disorders, J70.4 — Drug-induced interstitial lung disorders, unspecified, K12.32 — Oral mucositis (ulcerative) due to other drugs, K52.1 — Toxic gastroenteritis and colitis, K59.03 — Drug induced constipation, +237 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “Crisis”, “Hypotension”; these codes share that main term but sit in a different category of the Tabular List.

D57.03 — Hb-SS disease with cerebral vascular involvement (sickle-cell, with, cerebral vascular involvement), D57.09 — Hb-SS disease with crisis with other specified complication (sickle-cell, with, complication specified NEC), E27.2 — Addisonian crisis (adrenal), F43.0 — Acute stress reaction (state), F45.8 — Other somatoform disorders (oculogyric, psychogenic), F64.2 — Gender identity disorder of childhood (psychosexual identity), F93.8 — Other childhood emotional disorders (emotional, specific to childhood and adolescence), G90.3 — Multi-system degeneration of the autonomic nervous system (orthostatic, neurogenic), G96.810 — Intracranial hypotension, unspecified (intracranial), G96.811 — Intracranial hypotension, spontaneous (intracranial, spontaneous), G96.819 — Other intracranial hypotension (intracranial, specified NEC), G97.2 — Intracranial hypotension following ventricular shunting (intracranial, following, ventricular shunting), G97.83 — Intracranial hypotension following lumbar cerebrospinal fluid shunting (intracranial, following, lumbar cerebrospinal fluid shunting), G97.84 — Intracranial hypotension following other procedure (intracranial, following, specified procedure NEC), H51.8 — Other specified disorders of binocular movement (oculogyric), K90.0 — Celiac disease (celiac), N13.8 — Other obstructive and reflux uropathy (Dietl's), N28.0 — Ischemia and infarction of kidney (renal), O26.5 — Maternal hypotension syndrome (maternal, syndrome), R10.0 — Acute abdomen (abdomen), +4 more

Contextual Map

Every relationship of I95.2 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run I95.2 with these 10 related codes in Claim Check

Hierarchy

• I00-I99 — Chapter 9: Diseases of the Circulatory System (I00-I99) (I00-I99)[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I95-I99 — Other and unspecified disorders of the circulatory system[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026

Use Additional Code (15)

• T36 — Poisoning by, adverse effect of and underdosing of systemic antibiotics[Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T37 — Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics[Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T38 — Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified[Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T39 — Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics[Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T40 — Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens][Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T41 — Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gases[Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T42 — Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs[Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T43 — Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified[Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• and 7 more

Referenced by Excludes1 notes

• I95.1 — Orthostatic hypotension[Excludes1]: “orthostatic hypotension due to drugs (I95.2)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• R03.1 — Nonspecific low blood-pressure reading[Excludes1](via I95.-): “hypotension (I95.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Clinical classification (CCSR)

• INJ030 — Drug induced or toxic related condition[CCSR]— AHRQ CCSR for ICD-10-CM Diagnoses (HCUP)
• CIR031 — Hypotension[CCSR]— AHRQ CCSR for ICD-10-CM Diagnoses (HCUP)

MS-DRG Grouper

• DRG 312 — SYNCOPE AND COLLAPSE[MS-DRG]: “SYNCOPE AND COLLAPSE (MDC 05)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026

MDC crossing

• MDC 05 — Diseases and Disorders of the Circulatory System[MDC crossing]: “Diseases and Disorders of the Circulatory System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 17,209 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

• Crisis, nitritoid[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Hypotension (arterial) (constitutional), drug-induced[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Hypotension (arterial) (constitutional), orthostatic (chronic), due to drugs[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes

• I95 — Hypotension[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I95.0 — Idiopathic hypotension[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I95.1 — Orthostatic hypotension[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I95.3 — Hypotension of hemodialysis[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I95.8 — Other hypotension[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I95.81 — Postprocedural hypotension[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I95.89 — Other hypotension[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I95.9 — Hypotension, unspecified[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026

Change history

• FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data

CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page

Claim edits Official source data

CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page

Inpatient payment groups Official source data

CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page

Change history and date-of-service validity Official source data

CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page

Comparisons, relationships and the contextual map MedCoder structured relationship

Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears

Summary and FAQ answers MedCoder explanation

Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Nearest Codes in This Family

Official ICD-10-CM classifications closest to I95.2 in its code family, with their registry titles.

• I95 — Hypotension
• I95.0 — Idiopathic hypotension
• I95.1 — Orthostatic hypotension
• I95.3 — Hypotension of hemodialysis
• I95.8 — Other hypotension
• I95.81 — Postprocedural hypotension
• I95.89 — Other hypotension
• I95.9 — Hypotension, unspecified

View all codes in the I95 family