Q92.5 ICD-10-CM Code: Duplications with other complex rearrangements

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for Q92.5 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on Q92.5 itself; “inherited from” names the category or block whose note applies here.

Coder workflow for Q92.5

MedCoder structured workflow — derived from this code’s own official record

Before you code Q92.5

1. Q92.5’s title joins a condition with an associated condition or complication. Confirm each component is documented. Where the classification presumes the link through the “with” convention, only a provider statement that the conditions are unrelated defeats it. A combination code is assigned only when it fully identifies the documented conditions; a required second code for the stage, type or manifestation is still reported when the notes ask for it (Guidelines I.B.9, I.A.15).

   Guide: Combination codes →

2. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with Q92.5. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

   See the official tabular notes

Choose the right path

1. Does the documentation support a condition named in Q92.5’s Excludes1 note?
   Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
   No → Continue.

Consider Q92.5. Then review the Code Also note, and confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement

Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

The associated condition or complication

Whether the associated condition the title names is documented; the “with” convention presumes some links, and a provider statement that the conditions are unrelated defeats it (Guidelines I.A.15).

Official instructions as workflow

• Excludes1 — check before selecting Q92.5(1 note)

  Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with Q92.5: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

  See the official tabular notes · Guidelines I.A.12.a

• Excludes2 — not part of Q92.5(1 note)

  Coding workflow: The conditions named in this note are not included in Q92.5. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

  CompareE88.4

  See the official tabular notes · Guidelines I.A.12.b

• Code Also — related condition(1 note)

  Coding workflow: Review the related condition when both are documented and the instruction applies. A Code Also note does not fix sequencing; the order follows the circumstances of the encounter.

  ReviewQ93.7

  See the official tabular notes · Guidelines I.A.17

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Indexed Clinical Terms (3)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

• Accessory (congenital), chromosome (s) NEC (nonsex), with complex rearrangements NEC
• Duplication, duplex, chromosome NEC, with complex rearrangements NEC
• Trisomy (syndrome), chromosome specified NEC, partial, due to unbalanced translocation

Don’t confuse Q92.5 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of Q92.5 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

• Q90— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of trisomies of chromosomes 13, 18, 21 moves the case to Q90; the two are not reported together unless documented as unrelated.

  Full comparison: Q92.5 vs Q90 →

• Q91— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of trisomies of chromosomes 13, 18, 21 moves the case to Q91; the two are not reported together unless documented as unrelated.

  Full comparison: Q92.5 vs Q91 →

• Q92.9— Specificity relationship (Review)

  Overlapping diagnoses in the same category.

  Overlapping codes in the same category — the documentation decides which is the more specific fit.

  What moves you there: A record that documents no more than “Trisomy and partial trisomy of autosomes, unspecified” takes Q92.9; specificity in the record moves it back here.

  Full comparison: Q92.5 vs Q92.9 →

• E88.4— Excludes2 relationship (Informational)

  Distinct conditions — both may be reported.

  A distinct condition — both may be reported when both are documented.

  What moves you there: Documentation of mitochondrial metabolic disorders adds E88.4; it is not part of this code and both may be reported when both are documented.

  Full comparison: Q92.5 vs E88.4 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Decision Points

The directives on this code's own record, as a pre-claim checklist.

1. 1 Code Also note — a second code may apply; the guidelines leave its sequencing to the circumstances of the encounter. See the Code Also notes
2. 1 Excludes1 entry — codes named there are generally not reported together with this code (Guidelines I.A.12.a). See the Excludes1 notes
3. 1 Excludes2 entry — those conditions are not part of this code and may be reported additionally when documented. See the Excludes2 notes

Checklist rows are derived from this code's own official directives; the wording of each check is MedCoder editorial. The official notes themselves are in the sections each row links to.

Verify Before Coding

• No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name Q92.5 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 11 Excludes1 notes across 3 chapters: E25 — Adrenogenital disorders (via Q92.-), Q50 — Congenital malformations of ovaries, fallopian tubes and broad ligaments (via Q92.-), Q50-Q56 — Congenital malformations of genital organs (Q50-Q56) (via Q92.-), Q51 — Congenital malformations of uterus and cervix (via Q92.-), Q52 — Other congenital malformations of female genitalia (via Q92.-), Q53 — Undescended and ectopic testicle (via Q92.-), Q54 — Hypospadias (via Q92.-), Q55 — Other congenital malformations of male genital organs (via Q92.-), Q56 — Indeterminate sex and pseudohermaphroditism (via Q92.-), Q92.2 — Partial trisomy, Z15 — Genetic susceptibility to disease (via Q92.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 1 Code First instruction: D84.81 — Immunodeficiency due to conditions classified elsewhere (via Q92.-).

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

Referenced by 1 Code Also instruction: Q93.7 — Deletions with other complex rearrangements.

These codes suggest coding this condition alongside when both are present.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 1 MS-DRG: DRG 951 (MDC 23).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):MAL009 — Chromosomal abnormalities (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Chromosomal abnormalities).

Q91.1 — Trisomy 18, mosaicism (mitotic nondisjunction), Q91.2 — Trisomy 18, translocation, Q91.3 — Trisomy 18, unspecified, Q91.4 — Trisomy 13, nonmosaicism (meiotic nondisjunction), Q91.5 — Trisomy 13, mosaicism (mitotic nondisjunction), Q91.6 — Trisomy 13, translocation, Q91.7 — Trisomy 13, unspecified, Q92.0 — Whole chromosome trisomy, nonmosaicism (meiotic nondisjunction), Q92.1 — Whole chromosome trisomy, mosaicism (mitotic nondisjunction), Q92.2 — Partial trisomy, Q92.61 — Marker chromosomes in normal individual, Q92.62 — Marker chromosomes in abnormal individual, Q92.7 — Triploidy and polyploidy, Q92.8 — Other specified trisomies and partial trisomies of autosomes, Q92.9 — Trisomy and partial trisomy of autosomes, unspecified, Q93.0 — Whole chromosome monosomy, nonmosaicism (meiotic nondisjunction), Q93.1 — Whole chromosome monosomy, mosaicism (mitotic nondisjunction), Q93.2 — Chromosome replaced with ring, dicentric or isochromosome, Q93.3 — Deletion of short arm of chromosome 4, Q93.4 — Deletion of short arm of chromosome 5, +56 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “Accessory”, “Trisomy”; these codes share that main term but sit in a different category of the Tabular List.

Q82.8 — Other specified congenital malformations of skin (skin tags), Q83.1 — Accessory breast (breast tissue, axilla), Q83.3 — Accessory nipple (nipple), Q89.09 — Congenital malformations of spleen (spleen), Q89.1 — Congenital malformations of adrenal gland (adrenal gland), Q89.2 — Congenital malformations of other endocrine glands (thymus gland), Q89.89 — Other specified congenital malformations (genitourinary organs NEC), Q90.0 — Trisomy 21, nonmosaicism (meiotic nondisjunction) (21, meiotic nondisjunction), Q90.1 — Trisomy 21, mosaicism (mitotic nondisjunction) (21, mosaicism), Q90.2 — Trisomy 21, translocation (21, translocation), Q90.9 — Down syndrome, unspecified (21), Q91.0 — Trisomy 18, nonmosaicism (meiotic nondisjunction) (18, meiotic nondisjunction), Q91.1 — Trisomy 18, mosaicism (mitotic nondisjunction) (18, mosaicism), Q91.2 — Trisomy 18, translocation (18, translocation), Q91.3 — Trisomy 18, unspecified (18), Q91.4 — Trisomy 13, nonmosaicism (meiotic nondisjunction) (13, meiotic nondisjunction), Q91.5 — Trisomy 13, mosaicism (mitotic nondisjunction) (13, mosaicism), Q91.6 — Trisomy 13, translocation (13, translocation), Q91.7 — Trisomy 13, unspecified (13), Q97.8 — Other specified sex chromosome abnormalities, female phenotype (chromosome, sex, female phenotype), +56 more

Contextual Map

Every relationship of Q92.5 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run Q92.5 with these 10 related codes in Claim Check

Hierarchy

• Q00-QA1 — Chapter 17: Congenital Malformations, Deformations and Chromosomal Abnormalities (Q00-QA1) (Q00-QA1)[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• Q90-Q99 — Chromosomal abnormalities, not elsewhere classified[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026

Code Also

• Q93.7 — Deletions with other complex rearrangements[Code Also]: “any associated deletions due to unbalanced translocations, inversions and insertions (Q93.7)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Referenced by Excludes1 notes (11)

• E25 — Adrenogenital disorders[Excludes1](via Q92.-): “chromosomal abnormalities (Q90-Q99)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• Q50 — Congenital malformations of ovaries, fallopian tubes and broad ligaments[Excludes1](via Q92.-): “syndromes associated with anomalies in the number and form of chromosomes (Q90-Q99)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• Q50-Q56 — Congenital malformations of genital organs (Q50-Q56)[Excludes1](via Q92.-): “syndromes associated with anomalies in the number and form of chromosomes (Q90-Q99)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• Q51 — Congenital malformations of uterus and cervix[Excludes1](via Q92.-): “syndromes associated with anomalies in the number and form of chromosomes (Q90-Q99)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• Q52 — Other congenital malformations of female genitalia[Excludes1](via Q92.-): “syndromes associated with anomalies in the number and form of chromosomes (Q90-Q99)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• Q53 — Undescended and ectopic testicle[Excludes1](via Q92.-): “syndromes associated with anomalies in the number and form of chromosomes (Q90-Q99)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• Q54 — Hypospadias[Excludes1](via Q92.-): “syndromes associated with anomalies in the number and form of chromosomes (Q90-Q99)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• Q55 — Other congenital malformations of male genital organs[Excludes1](via Q92.-): “syndromes associated with anomalies in the number and form of chromosomes (Q90-Q99)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• and 3 more

Referenced by Code First instructions

• D84.81 — Immunodeficiency due to conditions classified elsewhere[Code First](via Q92.-): “chromosomal abnormalities (Q90-Q99)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Referenced by Code Also instructions

• Q93.7 — Deletions with other complex rearrangements[Code Also]: “any associated duplications due to unbalanced translocations, inversions and insertions (Q92.5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Clinical classification (CCSR)

• MAL009 — Chromosomal abnormalities[CCSR]— AHRQ CCSR for ICD-10-CM Diagnoses (HCUP)

MS-DRG Grouper

• DRG 951 — OTHER FACTORS INFLUENCING HEALTH STATUS[MS-DRG]: “OTHER FACTORS INFLUENCING HEALTH STATUS (MDC 23)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026

MDC crossing

• MDC 23 — Factors Influencing Health Status and Other Contacts with Health Services[MDC crossing]: “Factors Influencing Health Status and Other Contacts with Health Services — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 1,235 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

• Accessory (congenital), chromosome (s) NEC (nonsex), with complex rearrangements NEC[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Duplication, duplex, chromosome NEC, with complex rearrangements NEC[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Trisomy (syndrome), chromosome specified NEC, partial, due to unbalanced translocation[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes (10)

• Q92 — Other trisomies and partial trisomies of the autosomes, not elsewhere classified[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• Q92.0 — Whole chromosome trisomy, nonmosaicism (meiotic nondisjunction)[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• Q92.1 — Whole chromosome trisomy, mosaicism (mitotic nondisjunction)[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• Q92.2 — Partial trisomy[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• Q92.6 — Marker chromosomes[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• Q92.61 — Marker chromosomes in normal individual[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• Q92.62 — Marker chromosomes in abnormal individual[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• Q92.7 — Triploidy and polyploidy[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• and 2 more

Change history

• FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data

CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page

Claim edits Official source data

CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page

Inpatient payment groups Official source data

CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page

Change history and date-of-service validity Official source data

CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page

Comparisons, relationships and the contextual map MedCoder structured relationship

Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears

Summary and FAQ answers MedCoder explanation

Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Nearest Codes in This Family

Official ICD-10-CM classifications closest to Q92.5 in its code family, with their registry titles.

• Q92 — Other trisomies and partial trisomies of the autosomes, not elsewhere classified
• Q92.0 — Whole chromosome trisomy, nonmosaicism (meiotic nondisjunction)
• Q92.1 — Whole chromosome trisomy, mosaicism (mitotic nondisjunction)
• Q92.2 — Partial trisomy
• Q92.6 — Marker chromosomes
• Q92.61 — Marker chromosomes in normal individual
• Q92.62 — Marker chromosomes in abnormal individual
• Q92.7 — Triploidy and polyploidy
• Q92.8 — Other specified trisomies and partial trisomies of autosomes
• Q92.9 — Trisomy and partial trisomy of autosomes, unspecified

View all codes in the Q92 family