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R53.0 ICD-10-CM Code: Neoplastic (malignant) related fatigue

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
1 code-first instruction

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 947 — SIGNS AND SYMPTOMS WITH MCC (MDC 23)
  • MS-DRG 948 — SIGNS AND SYMPTOMS WITHOUT MCC (MDC 23)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for R53.0 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Trace:FY2027 changesChange historyRelease, file and checksum

Code First

Underlying conditions that must be sequenced before this code.

  • associated neoplasm

Coder workflow for R53.0

MedCoder structured workflow — derived from this code’s own official record

Before you code R53.0

  1. Check whether an established diagnosis that explains this sign or symptom is documented. If one is, review whether the documented diagnosis changes the coding pathway: a symptom that is integral to a confirmed diagnosis is not reported separately, while one not routinely associated with it may be. Signs and symptoms are reported when no definitive diagnosis is established (Guidelines I.B.4, I.B.5, I.B.6, I.C.18.b).

    Guide: Symptom code vs confirmed diagnosis →

Choose the right path

  1. Is an established diagnosis that explains this sign or symptom documented?
    Yes → Review whether the documented diagnosis changes the coding pathway: a symptom integral to it is not reported separately.
    No → Continue — the sign or symptom code stands when no definitive diagnosis is established.
  2. Is the underlying (etiologic) condition the Code First note names documented?
    Yes → Sequence the underlying condition first, then R53.0.
    No → Continue; do not add an underlying condition the record does not document.

Consider R53.0. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
The underlying (etiologic) condition
Named in the Code First note; sequenced before this code when documented (Guidelines I.A.13).

Official instructions as workflow

  • Code First — sequencing check(1 note)

    Coding workflow: Check whether the underlying or etiologic condition the note names is documented. When it is, sequence it before R53.0. Do not add an underlying condition the record does not document.

    See the official tabular notes · Guidelines I.A.13

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: The sign or symptom is documented, and the same record establishes a diagnosis that routinely includes it.

Coding question: Is R53.0 reported in addition to the diagnosis?

Path: Review the documented diagnosis and whether the classification treats this finding as integral to it.

Reason: Signs and symptoms integral to a confirmed diagnosis are not coded separately; those not routinely associated with it may be reported when present (Guidelines I.B.5, I.B.6, I.C.18.b).

Documentation: The underlying condition the Code First note names is documented alongside this condition.

Coding question: How are the two sequenced?

Path: Review the Code First note.

Reason: The underlying condition is sequenced first and the manifestation follows (Guidelines I.A.13).

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Code Overview

Neoplastic (malignant) related fatigue is a billable ICD-10-CM diagnosis code (R53.0).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (1)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Verify Before Coding

  • No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 2 MS-DRGs: DRG 947 (MDC 23), DRG 948 (MDC 23).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):NEO074 — Conditions due to neoplasm or the treatment of neoplasm (default); SYM007 — Malaise and fatigue.

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical categories (Conditions due to neoplasm or the treatment of neoplasm, Malaise and fatigue).

M84.562A — Pathological fracture in neoplastic disease, left tibia, initial encounter for fracture, M84.563A — Pathological fracture in neoplastic disease, right fibula, initial encounter for fracture, M84.564A — Pathological fracture in neoplastic disease, left fibula, initial encounter for fracture, M84.569A — Pathological fracture in neoplastic disease, unspecified tibia and fibula, initial encounter for fracture, M84.571A — Pathological fracture in neoplastic disease, right ankle, initial encounter for fracture, M84.572A — Pathological fracture in neoplastic disease, left ankle, initial encounter for fracture, M84.573A — Pathological fracture in neoplastic disease, unspecified ankle, initial encounter for fracture, M84.574A — Pathological fracture in neoplastic disease, right foot, initial encounter for fracture, M84.575A — Pathological fracture in neoplastic disease, left foot, initial encounter for fracture, M84.576A — Pathological fracture in neoplastic disease, unspecified foot, initial encounter for fracture, M84.58XA — Pathological fracture in neoplastic disease, other specified site, initial encounter for fracture, N52.36 — Erectile dysfunction following interstitial seed therapy, R18.0 — Malignant ascites, R53.1 — Weakness, R53.81 — Other malaise, R53.82 — Chronic fatigue, unspecified, R53.83 — Other fatigue, T80.810A — Extravasation of vesicant antineoplastic chemotherapy, initial encounter, T80.810D — Extravasation of vesicant antineoplastic chemotherapy, subsequent encounter, T80.810S — Extravasation of vesicant antineoplastic chemotherapy, sequela, +41 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Fatigue”; these codes share that main term but sit in a different category of the Tabular List.

F43.0 — Acute stress reaction (combat), F48.8 — Other specified nonpsychotic mental disorders (psychogenic), M62.89 — Other specified disorders of muscle (muscle), R49.8 — Other voice and resonance disorders (voice), R54 — Age-related physical debility (senile), T67.6 — Heat fatigue, transient (heat)

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Blood Glucose Test, Fecal Occult Blood Test (FOBT), Hepatitis Testing, HIV Screening Test, Thyroid Stimulating Hormone (TSH)

Contextual Map

Every relationship of R53.0 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 23 — Factors Influencing Health Status and Other Contacts with Health Services[MDC crossing]: “Factors Influencing Health Status and Other Contacts with Health Services — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 1,258 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2027

Index entries

  • Fatigue, neoplasm-related[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027

Nearest codes

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "R53.0 — Neoplastic (malignant) related fatigue." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/r53.0-neoplastic-malignant-related-fatigue

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Neoplastic (malignant) related fatigue

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027, and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to R53.0 in its code family, with their registry titles.

View all codes in the R53 family