T48.1X2A ICD-10-CM Code: Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], intentional self-harm, initial encounter

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for T48.1X2A in the official ICD-10-CM tabular list, quoted as published.

Notes without a marker are published on T48.1X2A itself; “inherited from” names the category or block whose note applies here.

7th Character Guide

"The appropriate 7th character is to be added to each code from category T48"

• A — initial encounter (this page’s code)
• D — subsequent encounter
• S — sequela

How the encounter character is assigned. “Initial encounter” means the patient is receiving active treatment for the condition — it is not limited to the first visit, and a different or new provider giving active treatment still assigns it. “Subsequent encounter” covers care during the healing or recovery phase after active treatment. “Sequela” is for complications or conditions that arise as a direct result of the original condition.

ICD-10-CM Official Guidelines for Coding and Reporting, Section I.C.19.a (paraphrased by MedCoder).

Variant codes in this family

T48.1X2A, T48.1X2D, T48.1X2S

Character meanings are CMS's official 7th-character extensions for this family, as carried in each variant code's official description; variant codes are registry rows. The explanation of how the encounter character is assigned is MedCoder editorial, distinct from the official content above it.

Coder workflow for T48.1X2A

MedCoder structured workflow — derived from this code’s own official record

Before you code T48.1X2A

1. A 7th character is required in this family. Confirm the documented encounter: initial (active treatment), subsequent (healing or recovery phase), or sequela. This page’s code carries “A”. “Initial” means active treatment, not the first visit (Guidelines I.C.19.a).

   See the 7th Character Guide · Guide: 7th characters: initial, subsequent, sequela →

2. Confirm whether the documentation describes a poisoning, an adverse effect of a correctly prescribed and administered drug, an underdosing, or a toxic effect, and the intent where the record states it: the Table of Drugs and Chemicals separates these by column, and the sequencing differs for each. Poisoning, adverse effect and underdosing guidelines (Guidelines I.C.19.e).

   See the Table of Drugs and Chemicals entries · Guide: Poisoning vs adverse effect vs underdosing →

3. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with T48.1X2A. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

   See the official tabular notes

Choose the right path

1. Does the documentation support a condition named in T48.1X2A’s Excludes1 note?
   Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
   No → Continue.

   ReviewO29.3

2. Is the underlying (etiologic) condition the Code First note names documented?
   Yes → Sequence the underlying condition first, then T48.1X2A.
   No → Continue; do not add an underlying condition the record does not document.

   ReviewT88.7, K29, L27

3. Is the encounter phase documented — active treatment, healing or recovery, or a sequela?
   Yes → Assign the matching 7th character; the variant codes are in the 7th Character Guide.
   No → The code is invalid without its 7th character — query for the missing element.

Consider T48.1X2A. Then work the Use Additional Code note, and confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement

Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

Encounter type

Active treatment, healing or recovery phase, or sequela — the basis of the 7th character (Guidelines I.C.19.a).

The underlying (etiologic) condition

Named in the Code First note; sequenced before this code when documented (Guidelines I.A.13).

The conditions the Use Additional Code note names

Reported with this code when documented; a conditional instruction (“if applicable”, “if known”) applies only when the record supports it.

External cause, place and activity

For the external cause codes reported with the injury or poisoning, where documented (Guidelines I.C.20.a).

Official instructions as workflow

• Excludes1 — check before selecting T48.1X2A(1 note)

  Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with T48.1X2A: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

  CompareO29.3

  See the official tabular notes · Guidelines I.A.12.a

• Excludes2 — not part of T48.1X2A(5 notes)

  Coding workflow: The conditions named in this note are not included in T48.1X2A. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

  CompareF55, D84.821

  See the official tabular notes · Guidelines I.A.12.b

• Code First — sequencing check(7 notes)

  Coding workflow: Check whether the underlying or etiologic condition the note names is documented. When it is, sequence it before T48.1X2A. Do not add an underlying condition the record does not document.

  ReviewT88.7, K29, L27

  See the official tabular notes · Guidelines I.A.13

• Use Additional Code — after identifying T48.1X2A(4 notes)

  Coding workflow: Check whether the documentation supports the additional code(s) the note names, and report them with T48.1X2A when it does. Where the instruction is conditional (“if applicable”, “if known”), it applies only when the record documents the condition.

  ReviewY63.6, Z91.12, Z91.13

  See the official tabular notes · Guidelines I.A.13

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Associated Substances (29)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Substances from the official ICD-10-CM Table of Drugs and Chemicals that map to this code.

• Aclatonium napadisilate
• Alcuronium (chloride)
• Atracurium besilate
• Carbolonium (bromide)
• Curare, curarine
• Cyclobenzaprine
• Decamethonium (bromide)
• Dimethyltubocurarinium chloride
• Fazadinium bromide
• Flaxedil
• Gallamine (triethiodide)
• Hexafluorenium bromide
• Hexafluronium (bromide)
• Hexanuorenium
• Hexcarbacholine bromide
• Laudexium
• Mivacurium chloride
• Myoneural blocking agents
• Neuromuscular blocking drug
• Pancuronium (bromide)
• Skeletal muscle relaxants
• Succinylcholine
• Suxamethonium (chloride)
• Suxethonium (chloride)
• Tubocurare
• Tubocurarine (chloride)
• Urari
• Vecuronium bromide
• Woorali

Don’t confuse T48.1X2A with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of T48.1X2A — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

• O29.3— Excludes1 conflict (Conflict)

  Not coded here — these two are mutually exclusive.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of toxic reaction to local anesthesia in pregnancy moves the case to O29.3; the two are not reported together unless documented as unrelated.

  Full comparison: T48.1X2A vs O29.3 →

• T48.1X2D— Encounter relationship (Review)

  Same underlying diagnosis, different encounter phase.

  The same diagnosis at a different phase of care; one encounter takes one 7th character.

  What moves you there: Documentation of a subsequent encounter moves the case to T48.1X2D.

  Full comparison: T48.1X2A vs T48.1X2D →

• T48.1X2S— Encounter relationship (Review)

  Same underlying diagnosis, different encounter phase.

  The same diagnosis at a different phase of care; one encounter takes one 7th character.

  What moves you there: Documentation of a sequela moves the case to T48.1X2S.

  Full comparison: T48.1X2A vs T48.1X2S →

• F10— Excludes2 relationship (Informational)

  Distinct conditions — both may be reported.

  A distinct condition — both may be reported when both are documented.

  What moves you there: Documentation of abuse and dependence of psychoactive substances adds F10; it is not part of this code and both may be reported when both are documented.

  Full comparison: T48.1X2A vs F10 →

• F19— Excludes2 relationship (Informational)

  Distinct conditions — both may be reported.

  A distinct condition — both may be reported when both are documented.

  What moves you there: Documentation of abuse and dependence of psychoactive substances adds F19; it is not part of this code and both may be reported when both are documented.

  Full comparison: T48.1X2A vs F19 →

• F55— Excludes2 relationship (Informational)

  Distinct conditions — both may be reported.

  A distinct condition — both may be reported when both are documented.

  What moves you there: Documentation of abuse of non-dependence-producing substances adds F55; it is not part of this code and both may be reported when both are documented.

  Full comparison: T48.1X2A vs F55 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Decision Points

The directives on this code's own record, as a pre-claim checklist.

1. A 7th character applies in this family. Confirm the documented encounter matches the character assigned. See the official 7th-character definitions and this code’s variants
2. Sequencing: 7 Code First instructions — the underlying condition is sequenced before this code when present. See the Code First notes
3. 4 Use Additional Code instructions — report the named additional code(s) when the documentation supports them. See the Use Additional Code notes
4. 1 Excludes1 entry — codes named there are generally not reported together with this code (Guidelines I.A.12.a). See the Excludes1 notes
5. 5 Excludes2 entries — those conditions are not part of this code and may be reported additionally when documented. See the Excludes2 notes

Checklist rows are derived from this code's own official directives; the wording of each check is MedCoder editorial. The official notes themselves are in the sections each row links to.

Verify Before Coding

• No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name T48.1X2A or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 11 Excludes2 notes across 2 chapters: T80 — Complications following infusion, transfusion and therapeutic injection (via T48.-), T80-T88 — Complications of surgical and medical care, not elsewhere classified (T80-T88) (via T48.-), T81 — Complications of procedures, not elsewhere classified (via T48.-), T82 — Complications of cardiac and vascular prosthetic devices, implants and grafts (via T48.-), T83 — Complications of genitourinary prosthetic devices, implants and grafts (via T48.-), T84 — Complications of internal orthopedic prosthetic devices, implants and grafts (via T48.-), T85 — Complications of other internal prosthetic devices, implants and grafts (via T48.-), T86 — Complications of transplanted organs and tissue (via T48.-), T87 — Complications peculiar to reattachment and amputation (via T48.-), T88 — Other complications of surgical and medical care, not elsewhere classified (via T48.-), Y63 — Failure in dosage during surgical and medical care (via T48.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

Referenced by 20 Code First instructions across 13 chapters: D64.2 — Secondary sideroblastic anemia due to drugs and toxins (via T48.-), E03.2 — Hypothyroidism due to medicaments and other exogenous substances (via T48.-), E09 — Drug or chemical induced diabetes mellitus (via T48.-), F02 — Dementia in other diseases classified elsewhere (via T48.-), G92.8 — Other toxic encephalopathy (via T48.-), G92.9 — Unspecified toxic encephalopathy (via T48.-), H35.38 — Toxic maculopathy (via T48.-), H91.0 — Ototoxic hearing loss (via T48.-), I42.7 — Cardiomyopathy due to drug and external agent (via T48.-), K22.1 — Ulcer of esophagus (via T48.-), K71 — Toxic liver disease (via T48.-), L53.0 — Toxic erythema (via T48.-), M34.2 — Systemic sclerosis induced by drug and chemical (via T48.-), N14 — Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions (via T48.-), P58.4 — Neonatal jaundice due to drugs or toxins transmitted from mother or given to newborn (via T48.-), Z91.12 — Patient's intentional underdosing of medication regimen (via T48.-), Z91.13 — Patient's unintentional underdosing of medication regimen (via T48.-), Z91.14 — Patient's other noncompliance with medication regimen (via T48.-), Z91.A2 — Caregiver's intentional underdosing of patient's medication regimen (via T48.-), Z91.A3 — Caregiver's unintentional underdosing of patient's medication regimen (via T48.-).

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

Referenced by 99 Use Additional Code instructions across 15 chapters: D46 — Myelodysplastic syndromes (via T48.-), D52.1 — Drug-induced folate deficiency anemia (via T48.-), D59.0 — Drug-induced autoimmune hemolytic anemia (via T48.-), D59.2 — Drug-induced nonautoimmune hemolytic anemia (via T48.-), D59.39 — Other hemolytic-uremic syndrome (via T48.-), D61.1 — Drug-induced aplastic anemia (via T48.-), D64.2 — Secondary sideroblastic anemia due to drugs and toxins (via T48.-), D70.2 — Other drug-induced agranulocytosis (via T48.-), D72.12 — Drug rash with eosinophilia and systemic symptoms syndrome (via T48.-), D84.821 — Immunodeficiency due to drugs (via T48.-), D89.3 — Immune reconstitution syndrome (via T48.-), E03.2 — Hypothyroidism due to medicaments and other exogenous substances (via T48.-), E06.4 — Drug-induced thyroiditis (via T48.-), E09 — Drug or chemical induced diabetes mellitus (via T48.-), E16.0 — Drug-induced hypoglycemia without coma (via T48.-), E22.1 — Hyperprolactinemia (via T48.-), E23.1 — Drug-induced hypopituitarism (via T48.-), E24.2 — Drug-induced Cushing's syndrome (via T48.-), E25.8 — Other adrenogenital disorders (via T48.-), E27.3 — Drug-induced adrenocortical insufficiency (via T48.-), +79 more.

These codes instruct coders to additionally report this code when it applies.

Referenced by 1 Code Also instruction: Z91.1 — Patient's noncompliance with medical treatment and regimen (via T48.-).

These codes suggest coding this condition alongside when both are present.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

Not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity.

Named in the grouper logic of 2 MS-DRGs: DRG 917 (MDC 21), DRG 918 (MDC 21).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):MBD012 — Suicidal ideation/attempt/intentional self-harm (default); EXT014 — External cause codes: poisoning by drug; EXT021 — External cause codes: intent of injury, self-harm; INJ022 — Poisoning by drugs, initial encounter.

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same injury, other encounter phase

Same injury, coded at a different phase of treatment via the 7th character.

T48.1X2D — Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], intentional self-harm, subsequent encounterCompare T48.1X2A vs T48.1X2D →, T48.1X2S — Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], intentional self-harm, sequelaCompare T48.1X2A vs T48.1X2S →

Same CMS-HCC risk category (V28)

CMS maps these diagnoses to the same Hierarchical Condition Category (Major Depression, Moderate or Severe, without Psychosis) for risk-adjusted payment.

T47.1X2A — Poisoning by other antacids and anti-gastric-secretion drugs, intentional self-harm, initial encounter, T47.2X2A — Poisoning by stimulant laxatives, intentional self-harm, initial encounter, T47.3X2A — Poisoning by saline and osmotic laxatives, intentional self-harm, initial encounter, T47.4X2A — Poisoning by other laxatives, intentional self-harm, initial encounter, T47.5X2A — Poisoning by digestants, intentional self-harm, initial encounter, T47.6X2A — Poisoning by antidiarrheal drugs, intentional self-harm, initial encounter, T47.7X2A — Poisoning by emetics, intentional self-harm, initial encounter, T47.8X2A — Poisoning by other agents primarily affecting gastrointestinal system, intentional self-harm, initial encounter, T47.92XA — Poisoning by unspecified agents primarily affecting the gastrointestinal system, intentional self-harm, initial encounter, T48.0X2A — Poisoning by oxytocic drugs, intentional self-harm, initial encounter, T48.202A — Poisoning by unspecified drugs acting on muscles, intentional self-harm, initial encounter, T48.292A — Poisoning by other drugs acting on muscles, intentional self-harm, initial encounter, T48.3X2A — Poisoning by antitussives, intentional self-harm, initial encounter, T48.4X2A — Poisoning by expectorants, intentional self-harm, initial encounter, T48.5X2A — Poisoning by other anti-common-cold drugs, intentional self-harm, initial encounter, T48.6X2A — Poisoning by antiasthmatics, intentional self-harm, initial encounter, T48.902A — Poisoning by unspecified agents primarily acting on the respiratory system, intentional self-harm, initial encounter, T48.992A — Poisoning by other agents primarily acting on the respiratory system, intentional self-harm, initial encounter, T49.0X2A — Poisoning by local antifungal, anti-infective and anti-inflammatory drugs, intentional self-harm, initial encounter, T49.1X2A — Poisoning by antipruritics, intentional self-harm, initial encounter, +350 more

Related risk categories

These categories interact through CMS's HCC hierarchy — one can suppress the other's risk-adjustment weight when both are present on a claim.

Schizophrenia, Psychosis, Except Schizophrenia, Personality Disorders; Anorexia/Bulimia Nervosa, Bipolar Disorders without Psychosis

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical categories (Suicidal ideation/attempt/intentional self-harm, External cause codes: poisoning by drug, External cause codes: intent of injury, self-harm, Poisoning by drugs, initial encounter).

+905 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Gamma-glutamyl Transferase (GGT) Test

Contextual Map

Every relationship of T48.1X2A in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run T48.1X2A with these 24 related codes in Claim Check

Hierarchy

• S00-T88 — Chapter 19: Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88) (S00-T88)[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T36-T50 — Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T47-T50 — Hormones & Systemic Agents[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026

Referenced by Excludes2 notes (11)

• T80 — Complications following infusion, transfusion and therapeutic injection[Excludes2](via T48.-): “poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T80-T88 — Complications of surgical and medical care, not elsewhere classified (T80-T88)[Excludes2](via T48.-): “poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T81 — Complications of procedures, not elsewhere classified[Excludes2](via T48.-): “poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T82 — Complications of cardiac and vascular prosthetic devices, implants and grafts[Excludes2](via T48.-): “poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T83 — Complications of genitourinary prosthetic devices, implants and grafts[Excludes2](via T48.-): “poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T84 — Complications of internal orthopedic prosthetic devices, implants and grafts[Excludes2](via T48.-): “poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T85 — Complications of other internal prosthetic devices, implants and grafts[Excludes2](via T48.-): “poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T86 — Complications of transplanted organs and tissue[Excludes2](via T48.-): “poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• and 3 more

Referenced by Code First instructions (20)

• D64.2 — Secondary sideroblastic anemia due to drugs and toxins[Code First](via T48.-): “poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• E03.2 — Hypothyroidism due to medicaments and other exogenous substances[Code First](via T48.-): “poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• E09 — Drug or chemical induced diabetes mellitus[Code First](via T48.-): “poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• F02 — Dementia in other diseases classified elsewhere[Code First](via T48.-): “intoxications (T36-T65)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• G92.8 — Other toxic encephalopathy[Code First](via T48.-): “poisoning due to drug or toxin, if applicable, (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• G92.9 — Unspecified toxic encephalopathy[Code First](via T48.-): “poisoning due to drug or toxin, if applicable, (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• H35.38 — Toxic maculopathy[Code First](via T48.-): “poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• H91.0 — Ototoxic hearing loss[Code First](via T48.-): “poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• and 12 more

Referenced by Use Additional Code instructions (99)

• D46 — Myelodysplastic syndromes[Use Additional Code](via T48.-): “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• D52.1 — Drug-induced folate deficiency anemia[Use Additional Code](via T48.-): “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• D59.0 — Drug-induced autoimmune hemolytic anemia[Use Additional Code](via T48.-): “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• D59.2 — Drug-induced nonautoimmune hemolytic anemia[Use Additional Code](via T48.-): “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• D59.39 — Other hemolytic-uremic syndrome[Use Additional Code](via T48.-): “code, if applicable, for adverse effect to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• D61.1 — Drug-induced aplastic anemia[Use Additional Code](via T48.-): “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• D64.2 — Secondary sideroblastic anemia due to drugs and toxins[Use Additional Code](via T48.-): “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• D70.2 — Other drug-induced agranulocytosis[Use Additional Code](via T48.-): “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• and 91 more

Referenced by Code Also instructions

• Z91.1 — Patient's noncompliance with medical treatment and regimen[Code Also](via T48.-): “, if applicable, to identify underdosing of specific drug (T36-T50 with final character 6)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Clinical classification (CCSR)

• MBD012 — Suicidal ideation/attempt/intentional self-harm[CCSR]— AHRQ CCSR for ICD-10-CM Diagnoses (HCUP)
• EXT014 — External cause codes: poisoning by drug[CCSR]— AHRQ CCSR for ICD-10-CM Diagnoses (HCUP)
• EXT021 — External cause codes: intent of injury, self-harm[CCSR]— AHRQ CCSR for ICD-10-CM Diagnoses (HCUP)
• INJ022 — Poisoning by drugs, initial encounter[CCSR]— AHRQ CCSR for ICD-10-CM Diagnoses (HCUP)

Risk adjustment (CMS-HCC)

• HCC 155 — Major Depression, Moderate or Severe, without Psychosis [CMS-HCC]— CMS-HCC V28 · 2026

MS-DRG Grouper

• DRG 917 — POISONING AND TOXIC EFFECTS OF DRUGS WITH MCC[MS-DRG]: “POISONING AND TOXIC EFFECTS OF DRUGS WITH MCC (MDC 21)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 918 — POISONING AND TOXIC EFFECTS OF DRUGS WITHOUT MCC[MS-DRG]: “POISONING AND TOXIC EFFECTS OF DRUGS WITHOUT MCC (MDC 21)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026

MDC crossing

• MDC 21 — Injuries, Poisonings and Toxic Effects of Drugs[MDC crossing]: “Injuries, Poisonings and Toxic Effects of Drugs — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 32,029 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Drugs & chemicals (29)

• Aclatonium napadisilate — Aclatonium napadisilate — Poisoning, Intentional self-harm [Drug table]: “Aclatonium napadisilate (Poisoning, Intentional self-harm)”— CMS Table of Drugs and Chemicals · icd10cm-fy2026
• Alcuronium (chloride) — Alcuronium (chloride) — Poisoning, Intentional self-harm [Drug table]: “Alcuronium (chloride) (Poisoning, Intentional self-harm)”— CMS Table of Drugs and Chemicals · icd10cm-fy2026
• Atracurium besilate — Atracurium besilate — Poisoning, Intentional self-harm [Drug table]: “Atracurium besilate (Poisoning, Intentional self-harm)”— CMS Table of Drugs and Chemicals · icd10cm-fy2026
• Carbolonium (bromide) — Carbolonium (bromide) — Poisoning, Intentional self-harm [Drug table]: “Carbolonium (bromide) (Poisoning, Intentional self-harm)”— CMS Table of Drugs and Chemicals · icd10cm-fy2026
• Curare, curarine — Curare, curarine — Poisoning, Intentional self-harm [Drug table]: “Curare, curarine (Poisoning, Intentional self-harm)”— CMS Table of Drugs and Chemicals · icd10cm-fy2026
• Cyclobenzaprine — Cyclobenzaprine — Poisoning, Intentional self-harm [Drug table]: “Cyclobenzaprine (Poisoning, Intentional self-harm)”— CMS Table of Drugs and Chemicals · icd10cm-fy2026
• Decamethonium (bromide) — Decamethonium (bromide) — Poisoning, Intentional self-harm [Drug table]: “Decamethonium (bromide) (Poisoning, Intentional self-harm)”— CMS Table of Drugs and Chemicals · icd10cm-fy2026
• Dimethyltubocurarinium chloride — Dimethyltubocurarinium chloride — Poisoning, Intentional self-harm [Drug table]: “Dimethyltubocurarinium chloride (Poisoning, Intentional self-harm)”— CMS Table of Drugs and Chemicals · icd10cm-fy2026
• and 21 more

Nearest codes (40)

• T48 — Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory system[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T48.0X3S — Poisoning by oxytocic drugs, assault, sequela[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T48.0X4 — Poisoning by oxytocic drugs, undetermined[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T48.0X4A — Poisoning by oxytocic drugs, undetermined, initial encounter[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T48.0X4D — Poisoning by oxytocic drugs, undetermined, subsequent encounter[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T48.0X4S — Poisoning by oxytocic drugs, undetermined, sequela[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T48.0X5 — Adverse effect of oxytocic drugs[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T48.0X5A — Adverse effect of oxytocic drugs, initial encounter[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• and 32 more

Change history

• FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Common coding questions

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data

CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page

Claim edits Official source data

CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page

Inpatient payment groups Official source data

CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page

Risk adjustment Official source data

2026 Mid-Year Final ICD-10 Mappings + Model Software (cms.gov/files/zip/2026-midyear-final-icd-10-mappings.zip, 2026-midyear-final-model-software.zip) — CMS-HCC V28, PY2026 mid-year final release Release, file and checksum · Publisher’s page

Change history and date-of-service validity Official source data

CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page

Comparisons, relationships and the contextual map MedCoder structured relationship

Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears

Summary and FAQ answers MedCoder explanation

Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Nearest Codes in This Family

Official ICD-10-CM classifications closest to T48.1X2A in its code family, with their registry titles.

• T48.1X1 — Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], accidental (unintentional)
• T48.1X1A — Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], accidental (unintentional), initial encounter
• T48.1X1D — Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], accidental (unintentional), subsequent encounter
• T48.1X1S — Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], accidental (unintentional), sequela
• T48.1X2 — Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], intentional self-harm
• T48.1X2D — Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], intentional self-harm, subsequent encounter
• T48.1X2S — Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], intentional self-harm, sequela
• T48.1X3 — Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], assault
• T48.1X3A — Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], assault, initial encounter
• T48.1X3D — Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], assault, subsequent encounter

View all codes in the T48 family