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Z17.1 ICD-10-CM Code: Estrogen receptor negative status [ER-]

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
3 code-first instructions

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43, Appendix B.

  • MS-DRG 951 — OTHER FACTORS INFLUENCING HEALTH STATUS (MDC 23)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for Z17.1 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on Z17.1 itself; “inherited from” names the category or block whose note applies here.

Code First

Underlying conditions that must be sequenced before this code.

  • malignant neoplasm, such as:
  • malignant neoplasm of breast (C50.-)
  • malignant neoplasm of ovary (C56.-)

Source: inherited from Z17

Coder workflow for Z17.1

MedCoder structured workflow — derived from this code’s own official record

Before you code Z17.1

  1. Confirm the reason for the encounter this Z code records: the circumstance it records. Check whether the code may be reported as first-listed or principal — some Z codes are limited to one position — and do not report a history or status code for a condition documented as current. Z code categories and their reporting positions (Guidelines I.C.21.c, I.C.21.c.15).

    Guide: Z codes as principal or first-listed diagnosis →

Choose the right path

  1. Is the underlying (etiologic) condition the Code First note names documented?
    Yes → Sequence the underlying condition first, then Z17.1.
    No → Continue; do not add an underlying condition the record does not document.

    ReviewC50, C56

Consider Z17.1. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
The underlying (etiologic) condition
Named in the Code First note; sequenced before this code when documented (Guidelines I.A.13).
The reason for the encounter
Whether the code records the encounter’s purpose, a status, or a history — and whether it may be first-listed (Guidelines I.C.21.c).

Official instructions as workflow

  • Code First — sequencing check(3 notes)

    Coding workflow: Check whether the underlying or etiologic condition the note names is documented. When it is, sequence it before Z17.1. Do not add an underlying condition the record does not document.

    ReviewC50, C56

    See the official tabular notes · Guidelines I.A.13

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: The underlying condition the Code First note names is documented alongside this condition.

Coding question: How are the two sequenced?

Path: Review the Code First note.

Reason: The underlying condition is sequenced first and the manifestation follows (Guidelines I.A.13).

ReviewC50, C56

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Code Overview

Estrogen receptor negative status [ER-] is a billable ICD-10-CM diagnosis code (Z17.1).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (1)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Official Coding Guidelines

Official source data — quoted verbatim from the CMS/NCHS Official Guidelines

Official source data — quoted verbatim from the CMS/NCHS Official Guidelines

Verbatim excerpts from the ICD-10-CM Official Guidelines for Coding and Reporting (CMS/NCHS) that govern this code.

Chapter 21: Factors influencing health status and contact with health services (Z00-Z99)

Codes from category Z15 should generally not be used as principal or first-listed codes. If the patient has the condition to which he/she is susceptible, and that condition is the reason for the encounter, the code for the current condition should be sequenced first. If the patient is being seen for follow-up after completed treatment for this condition, and the condition no longer exists, a follow-up code should be sequenced first, followed by the appropriate personal history and genetic susceptibility codes. If the purpose of the encounter is genetic counseling associated with procreative management, code Z31.5, Encounter for genetic counseling, should be assigned as the first-listed code, followed by a code from category Z15. Additional codes should be assigned for any applicable family or personal history. Z16 Resistance to antimicrobial drugs This category indicates that a patient has a condition that is resistant to antimicrobial drug treatment. Sequence the infection code first. Z17 Estrogen, and other hormones and factors receptor status Z18 Retained foreign body fragments Z19 Hormone sensitivity malignancy status Z21 Asymptomatic HIV infection status This code indicates that a patient has tested positive for HIV but has manifested no signs or symptoms of the disease. Z22 Carrier of infectious disease Carrier status indicates that a person harbors the specific organisms of a disease without manifest symptoms and is capable of transmitting the infection. Z28.3 Underimmunization status

Verify Before Coding

  • Principal-diagnosis restriction. The Medicare Code Editor lists this code as unacceptable as a principal diagnosis: it describes a circumstance influencing health status rather than a current illness or injury being treated. It is valid as a secondary diagnosis.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name Z17.1 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 1 Use Additional Code instruction: C50 — Malignant neoplasm of breast (via Z17.-).

These codes instruct coders to additionally report this code when it applies.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 1 MS-DRG: DRG 951 (MDC 23).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):FAC029 — Genetic susceptibility to disease.

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Principal diagnosis restriction (Medicare Code Editor)

Not acceptable as a principal diagnosis on an inpatient claim.

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Genetic susceptibility to disease).

Z15.060 — Genetic susceptibility to colorectal cancer, Z15.068 — Genetic susceptibility to other malignant neoplasm of digestive system, Z15.07 — Genetic susceptibility to malignant neoplasm of urinary tract, Z15.09 — Genetic susceptibility to other malignant neoplasm, Z15.1 — Genetic susceptibility to epilepsy and neurodevelopmental disorders, Z15.2 — Genetic susceptibility to obesity, Z15.3 — Genetic susceptibility to kidney disease, Z15.81 — Genetic susceptibility to multiple endocrine neoplasia [MEN], Z15.89 — Genetic susceptibility to other disease, Z17.0 — Estrogen receptor positive status [ER+], Z17.21 — Progesterone receptor positive status, Z17.22 — Progesterone receptor negative status, Z17.31 — Human epidermal growth factor receptor 2 positive status, Z17.32 — Human epidermal growth factor receptor 2 negative status, Z17.410 — Hormone receptor positive with human epidermal growth factor receptor 2 positive status, Z17.411 — Hormone receptor positive with human epidermal growth factor receptor 2 negative status, Z17.420 — Hormone receptor negative with human epidermal growth factor receptor 2 positive status, Z17.421 — Hormone receptor negative with human epidermal growth factor receptor 2 negative status, Z19.1 — Hormone sensitive malignancy status, Z19.2 — Hormone resistant malignancy status, +5 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Status”; these codes share that main term but sit in a different category of the Tabular List.

E89.0 — Postprocedural hypothyroidism (thyroidectomy), E89.6 — Postprocedural adrenocortical (-medullary) hypofunction (adrenalectomy), F07.81 — Postconcussional syndrome (postcommotio cerebri), G40.901 — Epilepsy, unspecified, not intractable, with status epilepticus (epileptic, epilepticus), G80.3 — Athetoid cerebral palsy (marmoratus), I20.9 — Angina pectoris, unspecified (anginosus), K08.409 — Partial loss of teeth, unspecified cause, unspecified class (toothextraction), N90.811 — Female genital mutilation Type I status (clitorectomy), N90.812 — Female genital mutilation Type II status (clitorectomy, with excision of labia minora), N90.813 — Female genital mutilation Type III status (infibulation), Z19.1 — Hormone sensitive malignancy status (malignancy, hormone sensitive), Z19.2 — Hormone resistant malignancy status (malignancy, hormone resistant), Z21 — Asymptomatic human immunodeficiency virus [HIV] infection status (human immunodeficiency virusinfection, asymptomatic), Z28.31 — Underimmunization for COVID-19 status (underimmunization, COVID-19), Z28.310 — Unvaccinated for COVID-19 (underimmunization, COVID-19, unvaccinated), Z28.311 — Partially vaccinated for COVID-19 (underimmunization, COVID-19, partially vaccinated), Z28.39 — Other underimmunization status (underimmunization), Z33.1 — Pregnant state, incidental (pregnancy, incidental), Z39.0 — Encounter for care and examination of mother immediately after delivery (postpartum, care immediately after delivery), Z39.2 — Encounter for routine postpartum follow-up (postpartum), +71 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Alpha-Fetoprotein (AFP) Test

Contextual Map

Every relationship of Z17.1 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run Z17.1 with this related code in Claim Check

Hierarchy

Referenced by Use Additional Code instructions

  • C50 — Malignant neoplasm of breast[Use Additional Code](via Z17.-): “code to identify estrogen, and other hormones and factors receptor status (Z17.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 23 — Factors Influencing Health Status and Other Contacts with Health Services[MDC crossing]: “Factors Influencing Health Status and Other Contacts with Health Services — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 1,235 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

  • Status (post), estrogen receptor, negative[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes (15)

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
Coding guidelines Official source data
ICD-10-CM Official Guidelines for Coding and Reporting (FY2026), quoted by section Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "Z17.1 — Estrogen receptor negative status [ER-]." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/z17.1-estrogen-receptor-negative-status-er

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Estrogen receptor negative status [ER-]

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027 (effective October 1, 2026), and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to Z17.1 in its code family, with their registry titles.

View all codes in the Z17 family