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Z22.7 ICD-10-CM Code: Latent tuberculosis

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
3 inclusion terms · 2 Excludes1 · 1 Excludes2

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43, Appendix B.

  • MS-DRG 951 — OTHER FACTORS INFLUENCING HEALTH STATUS (MDC 23)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for Z22.7 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on Z22.7 itself; “inherited from” names the category or block whose note applies here.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • colonization status
  • suspected carrier

Source: inherited from Z22

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Latent tuberculosis infection (LTBI)

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Source: inherited from Z22

Coder workflow for Z22.7

MedCoder structured workflow — derived from this code’s own official record

Before you code Z22.7

  1. Confirm the reason for the encounter this Z code records: the circumstance it records. Check whether the code may be reported as first-listed or principal — some Z codes are limited to one position — and do not report a history or status code for a condition documented as current. Z code categories and their reporting positions (Guidelines I.C.21.c, I.C.21.c.15).

    Guide: Z codes as principal or first-listed diagnosis →

  2. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with Z22.7. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the documentation support a condition named in Z22.7’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewR76.12, R76.11

Consider Z22.7. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
The reason for the encounter
Whether the code records the encounter’s purpose, a status, or a history — and whether it may be first-listed (Guidelines I.C.21.c).

Official instructions as workflow

  • Excludes1 — check before selecting Z22.7(2 notes)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with Z22.7: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareR76.12, R76.11

    See the official tabular notes · Guidelines I.A.12.a

  • Excludes2 — not part of Z22.7(1 note)

    Coding workflow: The conditions named in this note are not included in Z22.7. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

    CompareB18

    See the official tabular notes · Guidelines I.A.12.b

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: Both the condition Z22.7 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewR76.12, R76.11

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Code Overview

Latent tuberculosis is a billable ICD-10-CM diagnosis code (Z22.7).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (4)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Official Coding Guidelines

Official source data — quoted verbatim from the CMS/NCHS Official Guidelines

Official source data — quoted verbatim from the CMS/NCHS Official Guidelines

Verbatim excerpts from the ICD-10-CM Official Guidelines for Coding and Reporting (CMS/NCHS) that govern this code.

Chapter 21: Factors influencing health status and contact with health services (Z00-Z99)

Codes from category Z15 should generally not be used as principal or first-listed codes. If the patient has the condition to which he/she is susceptible, and that condition is the reason for the encounter, the code for the current condition should be sequenced first. If the patient is being seen for follow-up after completed treatment for this condition, and the condition no longer exists, a follow-up code should be sequenced first, followed by the appropriate personal history and genetic susceptibility codes. If the purpose of the encounter is genetic counseling associated with procreative management, code Z31.5, Encounter for genetic counseling, should be assigned as the first-listed code, followed by a code from category Z15. Additional codes should be assigned for any applicable family or personal history. Z16 Resistance to antimicrobial drugs This category indicates that a patient has a condition that is resistant to antimicrobial drug treatment. Sequence the infection code first. Z17 Estrogen, and other hormones and factors receptor status Z18 Retained foreign body fragments Z19 Hormone sensitivity malignancy status Z21 Asymptomatic HIV infection status This code indicates that a patient has tested positive for HIV but has manifested no signs or symptoms of the disease. Z22 Carrier of infectious disease Carrier status indicates that a person harbors the specific organisms of a disease without manifest symptoms and is capable of transmitting the infection. Z28.3 Underimmunization status

Verify Before Coding

  • Principal-diagnosis restriction. The Medicare Code Editor lists this code as unacceptable as a principal diagnosis: it describes a circumstance influencing health status rather than a current illness or injury being treated. It is valid as a secondary diagnosis.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name Z22.7 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 8 Excludes1 notes across 2 chapters: R82.7 — Abnormal findings on microbiological examination of urine (via Z22.-), R83.5 — Abnormal microbiological findings in cerebrospinal fluid (via Z22.-), R84.5 — Abnormal microbiological findings in specimens from respiratory organs and thorax (via Z22.-), R85.5 — Abnormal microbiological findings in specimens from digestive organs and abdominal cavity (via Z22.-), R86.5 — Abnormal microbiological findings in specimens from male genital organs (via Z22.-), R87.5 — Abnormal microbiological findings in specimens from female genital organs (via Z22.-), R89.5 — Abnormal microbiological findings in specimens from other organs, systems and tissues (via Z22.-), Z20 — Contact with and (suspected) exposure to communicable diseases (via Z22.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 1 Use Additional Code instruction: O99.83 — Other infection carrier state complicating pregnancy, childbirth and the puerperium (via Z22.-).

These codes instruct coders to additionally report this code when it applies.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 1 MS-DRG: DRG 951 (MDC 23).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):FAC024 — Carrier status (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Principal diagnosis restriction (Medicare Code Editor)

Not acceptable as a principal diagnosis on an inpatient claim.

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Carrier status).

O99.835 — Other infection carrier state complicating the puerperium, Z22.0 — Carrier of typhoid, Z22.1 — Carrier of other intestinal infectious diseases, Z22.2 — Carrier of diphtheria, Z22.31 — Carrier of bacterial disease due to meningococci, Z22.321 — Carrier or suspected carrier of Methicillin susceptible Staphylococcus aureus, Z22.322 — Carrier or suspected carrier of Methicillin resistant Staphylococcus aureus, Z22.330 — Carrier of Group B streptococcus, Z22.338 — Carrier of other streptococcus, Z22.340 — Carrier of carbapenem-resistant Acinetobacter baumannii, Z22.341 — Carrier of carbapenem-sensitive Acinetobacter baumannii, Z22.349 — Carrier of Acinetobacter baumannii, unspecified, Z22.350 — Carrier of carbapenem-resistant Enterobacterales, Z22.358 — Carrier of other Enterobacterales, Z22.359 — Carrier of Enterobacterales, unspecified, Z22.39 — Carrier of other specified bacterial diseases, Z22.4 — Carrier of infections with a predominantly sexual mode of transmission, Z22.6 — Carrier of human T-lymphotropic virus type-1 [HTLV-1] infection, Z22.8 — Carrier of other infectious diseases, Z22.9 — Carrier of infectious disease, unspecified, +5 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Tuberculosis, tubercular, tuberculous”; these codes share that main term but sit in a different category of the Tabular List.

A18.52 — Tuberculous keratitis (cornea), A18.53 — Tuberculous chorioretinitis (chorioretinitis), A18.54 — Tuberculous iridocyclitis (uveal tract), A18.59 — Other tuberculosis of eye (optic), A18.6 — Tuberculosis of (inner) (middle) ear (ear), A18.7 — Tuberculosis of adrenal glands (adrenal), A18.81 — Tuberculosis of thyroid gland (thyroid gland), A18.82 — Tuberculosis of other endocrine glands (thymus gland), A18.83 — Tuberculosis of digestive tract organs, not elsewhere classified (lip), A18.84 — Tuberculosis of heart (heart), A18.85 — Tuberculosis of spleen (spleen, splenitis), A18.89 — Tuberculosis of other sites (breast), A19.0 — Acute miliary tuberculosis of a single specified site (miliary, acute, single specified site), A19.1 — Acute miliary tuberculosis of multiple sites (multiple, acute), A19.2 — Acute miliary tuberculosis, unspecified (miliary, acute), A19.8 — Other miliary tuberculosis (miliary, chronic), A19.9 — Miliary tuberculosis, unspecified (miliary), J65 — Pneumoconiosis associated with tuberculosis (miner's), P37.0 — Congenital tuberculosis (congenital), Z20.1 — Contact with and (suspected) exposure to tuberculosis (contact), +33 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Gamma-glutamyl Transferase (GGT) Test, Partial Thromboplastin Time (PTT) Test, Prothrombin Time Test and INR (PT/INR)

Contextual Map

Every relationship of Z22.7 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run Z22.7 with these 11 related codes in Claim Check

Hierarchy

Excludes1

Referenced by Excludes1 notes

Referenced by Use Additional Code instructions

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 23 — Factors Influencing Health Status and Other Contacts with Health Services[MDC crossing]: “Factors Influencing Health Status and Other Contacts with Health Services — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 1,235 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

  • Infection, infected, infective (opportunistic), tuberculous, latent (LTBI)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • LTBI (latent tuberculosis infection)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Tuberculosis, tubercular, tuberculous (calcification) (calcified) (caseous) (chromogenic acid-fast bacilli) (degeneration) (fibrocaseous) (fistula) (interstitial) (isolated circumscribed lesions) (necrosis) (parenchymatous) (ulcerative), abscess (respiratory), latent[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Tuberculosis, tubercular, tuberculous (calcification) (calcified) (caseous) (chromogenic acid-fast bacilli) (degeneration) (fibrocaseous) (fistula) (interstitial) (isolated circumscribed lesions) (necrosis) (parenchymatous) (ulcerative), latent[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes (25)

Change history

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
Coding guidelines Official source data
ICD-10-CM Official Guidelines for Coding and Reporting (FY2026), quoted by section Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "Z22.7 — Latent tuberculosis." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/z22.7-latent-tuberculosis

Change history

  • FY2020 — October 1, 2019
    Added to the code set
    Latent tuberculosis
    FY2020 changes

Nearest Codes in This Family

Official ICD-10-CM classifications closest to Z22.7 in its code family, with their registry titles.

View all codes in the Z22 family