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A02.25 ICD-10-CM Code: Salmonella pyelonephritis

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
2 inclusion terms

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43, Appendix B.

  • MS-DRG 867 — OTHER INFECTIOUS AND PARASITIC DISEASES DIAGNOSES WITH MCC (MDC 18)
  • MS-DRG 868 — OTHER INFECTIOUS AND PARASITIC DISEASES DIAGNOSES WITH CC (MDC 18)
  • MS-DRG 869 — OTHER INFECTIOUS AND PARASITIC DISEASES DIAGNOSES WITHOUT CC/MCC (MDC 18)
  • MS-DRG 974 — HIV WITH MAJOR RELATED CONDITION WITH MCC (MDC 25)
  • MS-DRG 975 — HIV WITH MAJOR RELATED CONDITION WITH CC (MDC 25)
  • MS-DRG 976 — HIV WITH MAJOR RELATED CONDITION WITHOUT CC/MCC (MDC 25)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for A02.25 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on A02.25 itself; “inherited from” names the category or block whose note applies here.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • infection or foodborne intoxication due to any Salmonella species other than S. typhi and S. paratyphi

Source: inherited from A02

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Salmonella tubulo-interstitial nephropathy

Code Overview

Salmonella pyelonephritis is a billable ICD-10-CM diagnosis code (A02.25).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (4)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Verify Before Coding

  • CC as a secondary diagnosis (FY2026). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name A02.25 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 2 Excludes1 notes across 2 chapters: A05 — Other bacterial foodborne intoxications, not elsewhere classified (via A02.-), N16 — Renal tubulo-interstitial disorders in diseases classified elsewhere.

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 6 Excludes2 notes: P35 — Congenital viral diseases (via A02.-), P35-P39 — Infections specific to the perinatal period (P35-P39) (via A02.-), P36 — Bacterial sepsis of newborn (via A02.-), P37 — Other congenital infectious and parasitic diseases (via A02.-), P38 — Omphalitis of newborn (via A02.-), P39 — Other infections specific to the perinatal period (via A02.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

Referenced by 1 Code First instruction: M49 — Spondylopathies in diseases classified elsewhere (via A02.-).

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 2 clinically related codes on its CMS exclusion list. Does not count toward severity when the stay groups to DRGs 974-976 (HIV with Major Related Condition).

Named in the grouper logic of 6 MS-DRGs: DRG 867 (MDC 18), DRG 868 (MDC 18), DRG 869 (MDC 18), DRG 974 (MDC 25), DRG 975 (MDC 25), DRG 976 (MDC 25).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):GEN004 — Urinary tract infections (default); INF003 — Bacterial infections.

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

A02.29 — Salmonella with other localized infection

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical categories (Urinary tract infections, Bacterial infections).

A18.10 — Tuberculosis of genitourinary system, unspecified, A18.13 — Tuberculosis of other urinary organs, A36.85 — Diphtheritic cystitis, A52.75 — Syphilis of kidney and ureter, A54.01 — Gonococcal cystitis and urethritis, unspecified, A56.01 — Chlamydial cystitis and urethritis, A59.03 — Trichomonal cystitis and urethritis, B37.41 — Candidal cystitis and urethritis, B37.49 — Other urogenital candidiasis, N10 — Acute pyelonephritis, N11.0 — Nonobstructive reflux-associated chronic pyelonephritis, N11.1 — Chronic obstructive pyelonephritis, N11.8 — Other chronic tubulo-interstitial nephritis, N11.9 — Chronic tubulo-interstitial nephritis, unspecified, N12 — Tubulo-interstitial nephritis, not specified as acute or chronic, N13.6 — Pyonephrosis, N15.1 — Renal and perinephric abscess, N30.00 — Acute cystitis without hematuria, N30.01 — Acute cystitis with hematuria, N30.10 — Interstitial cystitis (chronic) without hematuria, +438 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “Intoxication”, “Pyelonephritis”; these codes share that main term but sit in a different category of the Tabular List.

A05.0 — Foodborne staphylococcal intoxication (foodborne, due to, Staphylococcus), A05.1 — Botulism food poisoning (foodborne, classical), A05.2 — Foodborne Clostridium perfringens [Clostridium welchii] intoxication (foodborne, due to, Clostridium, welchii), A05.3 — Foodborne Vibrio parahaemolyticus intoxication (foodborne, due to, Vibrio, parahaemolyticus), A05.4 — Foodborne Bacillus cereus intoxication (foodborne, due to, Bacillus cereus), A05.5 — Foodborne Vibrio vulnificus intoxication (foodborne, due to, Vibrio, vulnificus), A05.8 — Other specified bacterial foodborne intoxications (foodborne, due to, bacterium, specified NEC), A05.9 — Bacterial foodborne intoxication, unspecified (foodborne), A23.9 — Brucellosis, unspecified (in, brucellosis), A36.84 — Diphtheritic tubulo-interstitial nephropathy (in, diphtheria), A41.9 — Sepsis, unspecified organism (in, sepsis), A52.75 — Syphilis of kidney and ureter (syphilitic), B58.83 — Toxoplasma tubulo-interstitial nephropathy (in, toxoplasmosis), C85.90 — Non-Hodgkin lymphoma, unspecified, unspecified site (in, lymphoma NEC), C90.0 — Multiple myeloma (in, multiple myeloma), C95.9 — Leukemia, unspecified (in, leukemia NEC), D86.84 — Sarcoid pyelonephritis (in, sarcoidosis), D89.1 — Cryoglobulinemia (in, cryoglobulinemia), E72.04 — Cystinosis (in, cystinosis), E74.09 — Other glycogen storage disease (in, glycogen storage disease), +24 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Iron Panel, Partial Thromboplastin Time (PTT) Test, Prothrombin Time Test and INR (PT/INR)

Contextual Map

Every relationship of A02.25 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run A02.25 with these 9 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes

Referenced by Excludes2 notes

Referenced by Code First instructions

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 18 — Infectious and Parasitic Diseases, Systemic or Unspecified Sites[MDC crossing]: “Infectious and Parasitic Diseases, Systemic or Unspecified Sites — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 1 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026
  • MDC 25 — Human Immunodeficiency Virus Infections[MDC crossing]: “Human Immunodeficiency Virus Infections — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

  • Disorder (of), tubulo-interstitial (in), Salmonella infection[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Infection, infected, infective (opportunistic), Salmonella (aertrycke) (arizonae) (cholerae-suis) (enteritidis) (gallinarum) (suipestifer) (typhimurium), localized, pyelonephritis[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Intoxication, foodborne, due to, Salmonella, with, localized infection (s), pyelonephritis[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Pyelonephritis, in (due to), Salmonella infection[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes (12)

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "A02.25 — Salmonella pyelonephritis." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/a02.25-salmonella-pyelonephritis

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Salmonella pyelonephritis

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027 (effective October 1, 2026), and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to A02.25 in its code family, with their registry titles.

View all codes in the A02 family