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C49.A1 ICD-10-CM Code: Gastrointestinal stromal tumor of esophagus

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0, Appendix B.

  • MS-DRG 374 — DIGESTIVE MALIGNANCY WITH MCC (MDC 06)
  • MS-DRG 375 — DIGESTIVE MALIGNANCY WITH CC (MDC 06)
  • MS-DRG 376 — DIGESTIVE MALIGNANCY WITHOUT CC/MCC (MDC 06)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Risk Adjustment (CMS-HCC)

Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.

  • HCC 23 — Prostate, Breast, and Other Cancers and Tumors

Other models: CMS-HCC V22 HCC 10 · RxHCC V08 HCC 20

Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.

Official Registry Overview & Definition

Gastrointestinal stromal tumor of esophagus is a billable ICD-10-CM diagnosis code (C49.A1).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for C49.A1 in the official ICD-10-CM tabular list.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • malignant neoplasm of blood vessel
  • malignant neoplasm of bursa
  • malignant neoplasm of cartilage
  • malignant neoplasm of fascia
  • malignant neoplasm of fat
  • malignant neoplasm of ligament, except uterine
  • malignant neoplasm of lymphatic vessel
  • malignant neoplasm of muscle
  • malignant neoplasm of synovia
  • malignant neoplasm of tendon (sheath)

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Indexed Clinical Terms (2)

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.

  • Tumor, stromal, gastrointestinal, esophagus
  • Tumor, stromal, gastrointestinal, malignant, esophagus

Frequently Compared Codes

The official Excludes notes on C49.A1 name these codes. Each comparison page covers when the two can — or must not — be reported together.

Change history

  • FY2017 — 2016-10-01
    Added to the code set
    Gastrointestinal stromal tumor of esophagus
    FY2017 changes

Verify Before Coding

  • CC as a secondary diagnosis (FY2026). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim.

Relationships & Classification

Official ICD-10-CM tabular notes on other codes that name C49.A1 or its code family.

3 Excludes1 notes: C40 (via C49.-), C40-C41 (via C49.-), C41 (via C49.-).

13 Excludes2 notes: C15 (via C49.A.-), C15-C26 (via C49.A.-), C16 (via C49.A.-), C17 (via C49.A.-), C18 (via C49.A.-), C19 (via C49.A.-), C20 (via C49.A.-), C21 (via C49.A.-), C22 (via C49.A.-), C23 (via C49.A.-) and 3 more.

1 Code First instructions: M63 (via C49.-).

Potential MS-DRG Relationships (FY2026)

CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 2 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 3 MS-DRGs: DRG 374 (MDC 06), DRG 375 (MDC 06), DRG 376 (MDC 06).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):NEO012 — Gastrointestinal cancers - esophagus (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Contextual Map

Every relationship of C49.A1 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

  • C00-D49 — Chapter 2: Neoplasms (C00-D49) (C00-D49) [Hierarchy]
  • C00-C75 — Malignant neoplasms, stated or presumed to be primary (of specified sites), and certain specified histologies, except neuroendocrine, and of lymphoid, hematopoietic and related tissue [Hierarchy]

Referenced by Excludes1 notes

  • C40 — Malignant neoplasm of bone and articular cartilage of limbs [Excludes1](via C49.-): “malignant neoplasm of synovia (C49.-)” · check together
  • C40-C41 — Malignant neoplasms of bone and articular cartilage (C40-C41) [Excludes1](via C49.-): “malignant neoplasm of synovia (C49.-)” · check together
  • C41 — Malignant neoplasm of bone and articular cartilage of other and unspecified sites [Excludes1](via C49.-): “malignant neoplasm of synovia (C49.-)” · check together

Referenced by Excludes2 notes (13)

  • C15 — Malignant neoplasm of esophagus [Excludes2](via C49.A.-): “gastrointestinal stromal tumors (C49.A-)” · check together
  • C15-C26 — Malignant neoplasms of digestive organs (C15-C26) [Excludes2](via C49.A.-): “gastrointestinal stromal tumors (C49.A-)” · check together
  • C16 — Malignant neoplasm of stomach [Excludes2](via C49.A.-): “gastrointestinal stromal tumors (C49.A-)” · check together
  • C17 — Malignant neoplasm of small intestine [Excludes2](via C49.A.-): “gastrointestinal stromal tumors (C49.A-)” · check together
  • C18 — Malignant neoplasm of colon [Excludes2](via C49.A.-): “gastrointestinal stromal tumors (C49.A-)” · check together
  • C19 — Malignant neoplasm of rectosigmoid junction [Excludes2](via C49.A.-): “gastrointestinal stromal tumors (C49.A-)” · check together
  • C20 — Malignant neoplasm of rectum [Excludes2](via C49.A.-): “gastrointestinal stromal tumors (C49.A-)” · check together
  • C21 — Malignant neoplasm of anus and anal canal [Excludes2](via C49.A.-): “gastrointestinal stromal tumors (C49.A-)” · check together
  • and 5 more

Referenced by Code First instructions

  • M63 — Disorders of muscle in diseases classified elsewhere [Code First](via C49.-): “neoplasm (C49.-, C79.89, D21.-, D48.1-)” · check together

Clinical classification (CCSR)

  • NEO012 — Gastrointestinal cancers - esophagus [CCSR]

Risk adjustment (CMS-HCC)

  • HCC 23 — Prostate, Breast, and Other Cancers and Tumors [CMS-HCC]

Potential MS-DRG

  • CC — Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (CC).”
  • DRG 374 — DIGESTIVE MALIGNANCY WITH MCC [MS-DRG]: “DIGESTIVE MALIGNANCY WITH MCC (MDC 06)”
  • DRG 375 — DIGESTIVE MALIGNANCY WITH CC [MS-DRG]: “DIGESTIVE MALIGNANCY WITH CC (MDC 06)”
  • DRG 376 — DIGESTIVE MALIGNANCY WITHOUT CC/MCC [MS-DRG]: “DIGESTIVE MALIGNANCY WITHOUT CC/MCC (MDC 06)”

MDC crossing · procedures (5744)

  • MDC 06 — Diseases and Disorders of the Digestive System [MDC crossing]: “Diseases and Disorders of the Digestive System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs.”
  • 008Q0ZZ — Division of Vagus Nerve, Open Approach [Same-MDC procedure]: “Division of Vagus Nerve, Open Approach — grouped in MDC 06, the procedure side of this code's crossing.” · check together
  • 008Q3ZZ — Division of Vagus Nerve, Percutaneous Approach [Same-MDC procedure]: “Division of Vagus Nerve, Percutaneous Approach — grouped in MDC 06, the procedure side of this code's crossing.” · check together
  • 008Q4ZZ — Division of Vagus Nerve, Percutaneous Endoscopic Approach [Same-MDC procedure]: “Division of Vagus Nerve, Percutaneous Endoscopic Approach — grouped in MDC 06, the procedure side of this code's crossing.” · check together
  • 02BP3ZZ — Excision of Pulmonary Trunk, Percutaneous Approach [Same-MDC procedure]: “Excision of Pulmonary Trunk, Percutaneous Approach — grouped in MDC 06, the procedure side of this code's crossing.” · check together
  • 02BQ3ZZ — Excision of Right Pulmonary Artery, Percutaneous Approach [Same-MDC procedure]: “Excision of Right Pulmonary Artery, Percutaneous Approach — grouped in MDC 06, the procedure side of this code's crossing.” · check together
  • and 5739 more

Index entries

  • Tumor, stromal, gastrointestinal, esophagus[Index term]
  • Tumor, stromal, gastrointestinal, malignant, esophagus[Index term]

Nearest codes (23)

  • C49 — Malignant neoplasm of other connective and soft tissue [Sibling]
  • C49.0 — Malignant neoplasm of connective and soft tissue of head, face and neck [Sibling]
  • C49.1 — Malignant neoplasm of connective and soft tissue of upper limb, including shoulder [Sibling]
  • C49.10 — Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder [Sibling]
  • C49.11 — Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder [Sibling]
  • C49.12 — Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder [Sibling]
  • C49.2 — Malignant neoplasm of connective and soft tissue of lower limb, including hip [Sibling]
  • C49.20 — Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip [Sibling]
  • and 15 more

Change history

  • FY2017 — Added to the code set [Change history]

Nearest Codes in This Family

Official ICD-10-CM classifications closest to C49.A1 in its code family, with their registry titles.

  • C49.6 — Malignant neoplasm of connective and soft tissue of trunk, unspecified
  • C49.8 — Malignant neoplasm of overlapping sites of connective and soft tissue
  • C49.9 — Malignant neoplasm of connective and soft tissue, unspecified
  • C49.A — Gastrointestinal stromal tumor
  • C49.A0 — Gastrointestinal stromal tumor, unspecified site
  • C49.A2 — Gastrointestinal stromal tumor of stomach
  • C49.A3 — Gastrointestinal stromal tumor of small intestine
  • C49.A4 — Gastrointestinal stromal tumor of large intestine
  • C49.A5 — Gastrointestinal stromal tumor of rectum
  • C49.A9 — Gastrointestinal stromal tumor of other sites

View all codes in the C49 family