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E28.310 ICD-10-CM Code: Symptomatic premature menopause

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
1 inclusion term · 6 Excludes1

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43, Appendix B.

  • MS-DRG 742 — UTERINE AND ADNEXA PROCEDURES FOR NON-MALIGNANCY WITH CC/MCC (MDC 13)
  • MS-DRG 743 — UTERINE AND ADNEXA PROCEDURES FOR NON-MALIGNANCY WITHOUT CC/MCC (MDC 13)
  • MS-DRG 760 — MENSTRUAL AND OTHER FEMALE REPRODUCTIVE SYSTEM DISORDERS WITH CC/MCC (MDC 13)
  • MS-DRG 761 — MENSTRUAL AND OTHER FEMALE REPRODUCTIVE SYSTEM DISORDERS WITHOUT CC/MCC (MDC 13)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for E28.310 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on E28.310 itself; “inherited from” names the category or block whose note applies here.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Symptoms such as flushing, sleeplessness, headache, lack of concentration, associated with premature menopause

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Coder workflow for E28.310

MedCoder structured workflow — derived from this code’s own official record

Before you code E28.310

  1. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with E28.310. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the documentation support a condition named in E28.310’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewQ99.1, Q96, E23.0, E89.4, N64.3, N62

Consider E28.310. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

Official instructions as workflow

  • Excludes1 — check before selecting E28.310(6 notes)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with E28.310: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareQ99.1, Q96, E23.0, E89.4, N64.3, N62

    See the official tabular notes · Guidelines I.A.12.a

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: Both the condition E28.310 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewQ99.1, Q96, E23.0, E89.4, N64.3, N62

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Code Overview

Symptomatic premature menopause is a billable ICD-10-CM diagnosis code (E28.310).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (2)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Verify Before Coding

  • Age-restricted: the Medicare Code Editor lists this as an adult (age 15-124) diagnosis; other ages are presumed incorrect.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name E28.310 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 3 Excludes1 notes: N91 — Absent, scanty and rare menstruation (via E28.-), N95 — Menopausal and other perimenopausal disorders (via E28.31.-), N95.1 — Menopausal and female climacteric states.

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 1 Code First instruction: G63 — Polyneuropathy in diseases classified elsewhere (via E28.-).

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

Referenced by 1 Code Also instruction: Z91.B — Personal risk factor of exposure to diethylstilbestrol (via E28.31.-).

These codes suggest coding this condition alongside when both are present.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 4 MS-DRGs: DRG 742 (MDC 13), DRG 743 (MDC 13), DRG 760 (MDC 13), DRG 761 (MDC 13).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):GEN023 — Menopausal disorders (default); END015 — Other specified and unspecified endocrine disorders; GEN024 — Female infertility.

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical categories (Menopausal disorders, Other specified and unspecified endocrine disorders, Female infertility).

E27.2 — Addisonian crisis, E27.3 — Drug-induced adrenocortical insufficiency, E27.40 — Unspecified adrenocortical insufficiency, E27.49 — Other adrenocortical insufficiency, E27.5 — Adrenomedullary hyperfunction, E27.8 — Other specified disorders of adrenal gland, E27.9 — Disorder of adrenal gland, unspecified, E28.0 — Estrogen excess, E28.1 — Androgen excess, E28.2 — Polycystic ovarian syndrome, E28.319 — Asymptomatic premature menopause, E28.39 — Other primary ovarian failure, E28.8 — Other ovarian dysfunction, E28.9 — Ovarian dysfunction, unspecified, E29.0 — Testicular hyperfunction, E29.1 — Testicular hypofunction, E29.8 — Other testicular dysfunction, E29.9 — Testicular dysfunction, unspecified, E30.0 — Delayed puberty, E30.1 — Precocious puberty, +94 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “Premature”, “Menopause, menopausal”; these codes share that main term but sit in a different category of the Tabular List.

E27.0 — Other adrenocortical overactivity (adrenarche), E30.1 — Precocious puberty (puberty), E30.8 — Other disorders of puberty (thelarche), E34.8 — Other specified endocrine disorders (aging), E89.40 — Asymptomatic postprocedural ovarian failure (postirradiation, asymptomatic), E89.41 — Symptomatic postprocedural ovarian failure (postirradiation, symptomatic), F22 — Delusional disorders (paranoid state), F28 — Other psychotic disorder not due to a substance or known physiological condition (psychosis NEC), F32.2 — Major depressive disorder, single episode, severe without psychotic features (depression, agitated), F32.89 — Other specified depressive episodes (depression), F33.8 — Other recurrent depressive disorders (depression, recurrent episode), F33.9 — Major depressive disorder, recurrent, unspecified (depression, agitated, recurrent episode), F52.4 — Premature ejaculation (ejaculation), I49.1 — Atrial premature depolarization (beats, atrial), I49.2 — Junctional premature depolarization (contraction, junctional), I49.3 — Ventricular premature depolarization (ventricular systole), I49.40 — Unspecified premature depolarization (beats), I49.49 — Other premature depolarization (contraction, heart), N92.4 — Excessive bleeding in the premenopausal period (bleeding), N95.1 — Menopausal and female climacteric states (symptomatic), +4 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Iron Panel, Thyroid Stimulating Hormone (TSH)

Contextual Map

Every relationship of E28.310 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run E28.310 with these 5 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes

Referenced by Code First instructions

Referenced by Code Also instructions

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 13 — Diseases and Disorders of the Female Reproductive System[MDC crossing]: “Diseases and Disorders of the Female Reproductive System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 2,232 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

  • Menopause, menopausal (asymptomatic) (state), premature, symptomatic[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Premature, menopause, symptomatic[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes (10)

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "E28.310 — Symptomatic premature menopause." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/e28.310-symptomatic-premature-menopause

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Symptomatic premature menopause

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027 (effective October 1, 2026), and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to E28.310 in its code family, with their registry titles.

View all codes in the E28 family