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ICD-10/M35.07

M35.07 ICD-10-CM Code: Sjögren syndrome with central nervous system involvement

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0, Appendix B.

  • MS-DRG 545 — CONNECTIVE TISSUE DISORDERS WITH MCC (MDC 08)
  • MS-DRG 546 — CONNECTIVE TISSUE DISORDERS WITH CC (MDC 08)
  • MS-DRG 547 — CONNECTIVE TISSUE DISORDERS WITHOUT CC/MCC (MDC 08)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Official Registry Overview & Definition

Sjögren syndrome with central nervous system involvement is a billable ICD-10-CM diagnosis code (M35.07).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for M35.07 in the official ICD-10-CM tabular list.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • autoimmune disease NOS
  • collagen (vascular) disease NOS
  • systemic autoimmune disease
  • systemic collagen (vascular) disease

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code to identify associated manifestations

Change history

  • FY2022 — 2021-10-01
    Added to the code set
    Sjogren syndrome with central nervous system involvement
    FY2022 changes

Verify Before Coding

  • Billable — reportable as written.
  • CC as a secondary diagnosis (FY2026). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim.

Contextual Map

Every relationship of M35.07 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

  • M00-M99 — Chapter 13: Diseases of the Musculoskeletal System and Connective Tissue (M00-M99) (M00-M99) [Hierarchy]
  • M30-M36 — Systemic connective tissue disorders [Hierarchy]

Referenced by Excludes1 notes

  • K11.8 — Other diseases of salivary glands [Excludes1](via M35.0.-): “Sjögren syndrome (M35.0-)”
  • R68.2 — Dry mouth, unspecified [Excludes1](via M35.0.-): “dry mouth due to Sjögren syndrome (M35.0-)”

Referenced by Code Also instructions

  • I27.21 — Secondary pulmonary arterial hypertension [Code Also](via M35.0.-): “Sjögren syndrome (M35.0-)”

Clinical classification (CCSR)

  • MUS024 — Systemic lupus erythematosus and connective tissue disorders [CCSR]
  • NVS020 — Other nervous system disorders (neither hereditary nor degenerative) [CCSR]

Potential MS-DRG

  • CC — Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (CC).”
  • DRG 545 — CONNECTIVE TISSUE DISORDERS WITH MCC [MS-DRG]: “CONNECTIVE TISSUE DISORDERS WITH MCC (MDC 08)”
  • DRG 546 — CONNECTIVE TISSUE DISORDERS WITH CC [MS-DRG]: “CONNECTIVE TISSUE DISORDERS WITH CC (MDC 08)”
  • DRG 547 — CONNECTIVE TISSUE DISORDERS WITHOUT CC/MCC [MS-DRG]: “CONNECTIVE TISSUE DISORDERS WITHOUT CC/MCC (MDC 08)”

Index entries

  • Syndrome, Sjögren, with, central nervous system involvement[Index term]

Nearest codes (25)

  • M35 — Other systemic involvement of connective tissue [Sibling]
  • M35.0 — Sjögren syndrome [Sibling]
  • M35.00 — Sjögren syndrome, unspecified [Sibling]
  • M35.01 — Sjögren syndrome with keratoconjunctivitis [Sibling]
  • M35.02 — Sjögren syndrome with lung involvement [Sibling]
  • M35.03 — Sjögren syndrome with myopathy [Sibling]
  • M35.04 — Sjögren syndrome with tubulo-interstitial nephropathy [Sibling]
  • M35.05 — Sjögren syndrome with inflammatory arthritis [Sibling]
  • and 17 more

Change history

  • FY2022 — Added to the code set [Change history]

Referenced by Other Codes

Clinical classification (AHRQ CCSR):MUS024 — Systemic lupus erythematosus and connective tissue disorders (default); NVS020 — Other nervous system disorders (neither hereditary nor degenerative).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Potential MS-DRG Relationships (FY2026)

CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 13 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 3 MS-DRGs: DRG 545 (MDC 08), DRG 546 (MDC 08), DRG 547 (MDC 08).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Official ICD-10-CM tabular notes on other codes that name M35.07 or its code family.

2 Excludes1 notes across 2 chapters: K11.8 (via M35.0.-), R68.2 (via M35.0.-).

1 Code Also instructions: I27.21 (via M35.0.-).

Nearest Codes in This Family

Official ICD-10-CM classifications closest to M35.07 in its code family, with their registry titles.

  • M35.02 — Sjögren syndrome with lung involvement
  • M35.03 — Sjögren syndrome with myopathy
  • M35.04 — Sjögren syndrome with tubulo-interstitial nephropathy
  • M35.05 — Sjögren syndrome with inflammatory arthritis
  • M35.06 — Sjögren syndrome with peripheral nervous system involvement
  • M35.08 — Sjögren syndrome with gastrointestinal involvement
  • M35.09 — Sjögren syndrome with other organ involvement
  • M35.0A — Sjögren syndrome with glomerular disease
  • M35.0B — Sjögren syndrome with vasculitis
  • M35.0C — Sjögren syndrome with dental involvement

View all codes in the M35 family

Indexed Clinical Terms (1)

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.

  • Syndrome, Sjögren, with, central nervous system involvement