Name: Angiosarcoma of liver
Creator: MedCoder.ai

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives: 1 inclusion term · 3 Excludes1 · 1 Excludes2 · 4 use-additional codes
Risk adjustment: CMS-HCC V28: 1 category · CMS-HCC V22 category 9 · RxHCC V08 category 20

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

MS-DRG 435 — MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH MCC (MDC 07)
MS-DRG 436 — MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH CC (MDC 07)
MS-DRG 437 — MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITHOUT CC/MCC (MDC 07)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Risk Adjustment (CMS-HCC)

Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.

HCC 20 — Lung and Other Severe Cancers (supersedes HCC 21, HCC 22, HCC 23)

Other models: CMS-HCC V22 HCC 9 · RxHCC V08 HCC 20

Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for C22.3 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Notes without a marker are published on C22.3 itself; “inherited from” names the category or block whose note applies here.

Inclusion Terms

Alternative terms the tabular list files under this code.

Kupffer cell sarcoma

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

malignant neoplasm of biliary tract NOS (C24.9) inherited from C22Compare C22.3 vs C24.9 →
secondary malignant neoplasm of liver and intrahepatic bile duct (C78.7) inherited from C22Compare C22.3 vs C78.7 →
Kaposi's sarcoma of gastrointestinal sites (C46.4) inherited from C15-C26Compare C22.3 vs C46.4 →

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

gastrointestinal stromal tumors (C49.A-) Compare C22.3 vs C49.A →

Source: inherited from C15-C26

Use Additional Code

Supplementary codes the tabular list directs you to add.

Use additional code to identify:
alcohol abuse and dependence (F10.-)
hepatitis B (B16.-, B18.0-B18.1)
B18.0-B18.1: B18.0, B18.1
hepatitis C (B17.1-, B18.2)

Source: inherited from C22

Coder workflow for C22.3

MedCoder structured workflow — derived from this code’s own official record

Before you code C22.3

Confirm the documented site and behavior (this code’s block classifies malignant neoplasms), whether the site is primary or secondary, and whether the malignancy is current or a personal history: a previously excised malignancy with no further treatment and no evidence of disease is history, not current disease. Verify the site against the Table of Neoplasms. Neoplasm chapter guidelines (Guidelines I.C.2.a, I.C.2.d, I.C.2.m).
See the Table of Neoplasms entries · Guide: Active cancer vs history of cancer →
Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with C22.3. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).
See the official tabular notes

Choose the right path

Does the documentation support a condition named in C22.3’s Excludes1 note?
Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
No → Continue.
ReviewC24.9, C78.7, C46.4

Consider C22.3. Then work the Use Additional Code note, and confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement: Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
Anatomical site: At the most specific level the record states; a site the classification separates cannot be assumed from a procedure or a measurement.
The conditions the Use Additional Code note names: Reported with this code when documented; a conditional instruction (“if applicable”, “if known”) applies only when the record supports it.
Behavior and current-versus-history status: Malignant, in situ, benign or uncertain; primary or secondary; current disease or personal history (Guidelines I.C.2.m).

Official instructions as workflow

Excludes1 — check before selecting C22.3(3 notes)
Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with C22.3: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.
CompareC24.9, C78.7, C46.4
See the official tabular notes · Guidelines I.A.12.a
Excludes2 — not part of C22.3(1 note)
Coding workflow: The conditions named in this note are not included in C22.3. When the record documents both, both may be reported; the note is a boundary, not a prohibition.
CompareC49.A
See the official tabular notes · Guidelines I.A.12.b
Use Additional Code — after identifying C22.3(4 notes)
Coding workflow: Check whether the documentation supports the additional code(s) the note names, and report them with C22.3 when it does. Where the instruction is conditional (“if applicable”, “if known”), it applies only when the record documents the condition.
ReviewF10, B16, B17.1, B18.2
See the official tabular notes · Guidelines I.A.13

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: Both the condition C22.3 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewC24.9, C78.7, C46.4

Documentation: A condition the Use Additional Code note names is documented.

Coding question: Is a second code reported with C22.3?

Path: Review the Use Additional Code note and the code it names.

Reason: The additional code is reported when the record documents the condition; a conditional instruction applies only when its condition is met (Guidelines I.A.13).

ReviewF10, B16, B17.1, B18.2

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Code Overview

Angiosarcoma of liver is a billable ICD-10-CM diagnosis code (C22.3).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (3)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Don’t confuse C22.3 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of C22.3 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

C24.9— Excludes1 conflict (Excludes1 — generally not reported together)
Not coded here — the tabular list excludes this pair for the same encounter.
Not reported together with this code, except where the two conditions are documented as unrelated.
What moves you there: Documentation of malignant neoplasm of biliary tract NOS moves the case to C24.9; the two are not reported together unless documented as unrelated.
Full comparison: C22.3 vs C24.9 →
C78.7— Excludes1 conflict (Excludes1 — generally not reported together)
Not coded here — the tabular list excludes this pair for the same encounter.
Not reported together with this code, except where the two conditions are documented as unrelated.
What moves you there: Documentation of secondary malignant neoplasm of liver and intrahepatic bile duct moves the case to C78.7; the two are not reported together unless documented as unrelated.
Full comparison: C22.3 vs C78.7 →
C46.4— Excludes1 conflict (Excludes1 — generally not reported together)
Not coded here — the tabular list excludes this pair for the same encounter.
Not reported together with this code, except where the two conditions are documented as unrelated.
What moves you there: Documentation of Kaposi's sarcoma of gastrointestinal sites moves the case to C46.4; the two are not reported together unless documented as unrelated.
Full comparison: C22.3 vs C46.4 →
C22.8— Specificity relationship (Review)
Overlapping diagnoses in the same category.
Overlapping codes in the same category — the documentation decides which is the more specific fit.
What moves you there: A record that documents no more than “Malignant neoplasm of liver, primary, unspecified as to type” takes C22.8; specificity in the record moves it back here.
Full comparison: C22.3 vs C22.8 →
C49.A— Excludes2 relationship (Informational)
Distinct conditions — both may be reported.
A distinct condition — both may be reported when both are documented.
What moves you there: Documentation of gastrointestinal stromal tumors adds C49.A; it is not part of this code and both may be reported when both are documented.
Full comparison: C22.3 vs C49.A →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Decision Points

The directives on this code's own record, as a pre-claim checklist.

4 Use Additional Code instructions — report the named additional code(s) when the documentation supports them. See the Use Additional Code notes
3 Excludes1 entries — codes named there are generally not reported together with this code (Guidelines I.A.12.a). See the Excludes1 notes
1 Excludes2 entry — those conditions are not part of this code and may be reported additionally when documented. See the Excludes2 notes

Checklist rows are derived from this code's own official directives; the wording of each check is MedCoder editorial. The official notes themselves are in the sections each row links to.

Verify Before Coding

CC as a secondary diagnosis (FY2027). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 26 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 3 MS-DRGs: DRG 435 (MDC 07), DRG 436 (MDC 07), DRG 437 (MDC 07).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):NEO017 — Gastrointestinal cancers - liver (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

C22.0 — Liver cell carcinoma, C22.1 — Intrahepatic bile duct carcinoma, C22.2 — Hepatoblastoma, C22.4 — Other sarcomas of liver, C22.7 — Other specified carcinomas of liver, C22.8 — Malignant neoplasm of liver, primary, unspecified as to type, C22.9 — Malignant neoplasm of liver, not specified as primary or secondary, C26.0 — Malignant neoplasm of intestinal tract, part unspecified, C26.9 — Malignant neoplasm of ill-defined sites within the digestive system, C45.7 — Mesothelioma of other sites, C45.9 — Mesothelioma, unspecified, C46.4 — Kaposi's sarcoma of gastrointestinal sites, C76.8 — Malignant neoplasm of other specified ill-defined sites, C7A.00 — Malignant carcinoid tumor of unspecified site, C7A.098 — Malignant carcinoid tumors of other sites, C7A.1 — Malignant poorly differentiated neuroendocrine tumors, C7A.8 — Other malignant neuroendocrine tumors, C7B.00 — Secondary carcinoid tumors, unspecified site, C7B.1 — Secondary Merkel cell carcinoma, C80.0 — Disseminated malignant neoplasm, unspecified, +5 more

Same CMS-HCC risk category (V28)

CMS maps these diagnoses to the same Hierarchical Condition Category (Lung and Other Severe Cancers) for risk-adjusted payment.

Related risk categories

These categories interact through CMS's HCC hierarchy — one can suppress the other's risk-adjustment weight when both are present on a claim.

Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic, Cancer Metastatic to Bone, Other and Unspecified Metastatic Cancer; Acute Leukemia Except Myeloid, Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers, Lymphoma and Other Cancers, Bladder, Colorectal, and Other Cancers, Prostate, Breast, and Other Cancers and Tumors

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Gastrointestinal cancers - liver).

C22.0 — Liver cell carcinoma, C22.2 — Hepatoblastoma, C22.4 — Other sarcomas of liver, C22.7 — Other specified carcinomas of liver, C22.8 — Malignant neoplasm of liver, primary, unspecified as to type, C22.9 — Malignant neoplasm of liver, not specified as primary or secondary, D01.5 — Carcinoma in situ of liver, gallbladder and bile ducts

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Sarcoma”; these codes share that main term but sit in a different category of the Tabular List.

C41.0 — Malignant neoplasm of bones of skull and face (odontogenic, upper jaw), C41.1 — Malignant neoplasm of mandible (odontogenic), C46.0 — Kaposi's sarcoma of skin (Kaposi's, skin), C46.1 — Kaposi's sarcoma of soft tissue (Kaposi's, connective tissue), C46.2 — Kaposi's sarcoma of palate (Kaposi's, palate), C46.3 — Kaposi's sarcoma of lymph nodes (Kaposi's, lymph node), C46.4 — Kaposi's sarcoma of gastrointestinal sites (Kaposi's, colon), C46.5 — Kaposi's sarcoma of lung (Kaposi's, lung), C46.7 — Kaposi's sarcoma of other sites (Kaposi's, specified site NEC), C46.9 — Kaposi's sarcoma, unspecified (Kaposi's, unspecified site), C54.0 — Malignant neoplasm of isthmus uteri (stromal, isthmus), C54.1 — Malignant neoplasm of endometrium (stromal), C71.6 — Malignant neoplasm of cerebellum (cerebellar), C71.9 — Malignant neoplasm of brain, unspecified (monstrocellular, unspecified site), C92.3 — Myeloid sarcoma (myeloid), C96.22 — Mast cell sarcoma (mast cell), C96.4 — Sarcoma of dendritic cells (accessory cells) (Langerhans cell), C96.A — Histiocytic sarcoma (histiocytic)

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Alpha-Fetoprotein (AFP) Test, Fecal Occult Blood Test (FOBT), Gamma-glutamyl Transferase (GGT) Test, Iron Panel, Partial Thromboplastin Time (PTT) Test, Prothrombin Time Test and INR (PT/INR)

Contextual Map

Every relationship of C22.3 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

C00-D49 — Chapter 2: Neoplasms (C00-D49) (C00-D49)[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
C00-C75 — Malignant neoplasms, stated or presumed to be primary (of specified sites), and certain specified histologies, except neuroendocrine, and of lymphoid, hematopoietic and related tissue[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026

Clinical classification (CCSR)

NEO017 — Gastrointestinal cancers - liver[CCSR]— AHRQ CCSR for ICD-10-CM Diagnoses (HCUP)

Risk adjustment (CMS-HCC)

HCC 20 — Lung and Other Severe Cancers [CMS-HCC]: “Lung and Other Severe Cancers — supersedes HCC 21 (Lymphoma and Other Cancers), HCC 22 (Bladder, Colorectal, and Other Cancers), HCC 23 (Prostate, Breast, and Other Cancers and Tumors)”— CMS-HCC V28 · 2026

MS-DRG Grouper

CC — Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (CC).”— CMS MS-DRG Definitions Manual (Appendix C) · FY2027
DRG 435 — MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH MCC[MS-DRG]: “MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH MCC (MDC 07)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
DRG 436 — MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH CC[MS-DRG]: “MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH CC (MDC 07)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
DRG 437 — MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITHOUT CC/MCC[MS-DRG]: “MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITHOUT CC/MCC (MDC 07)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2027

MDC crossing

MDC 07 — Diseases and Disorders of the Hepatobiliary System and Pancreas[MDC crossing]: “Diseases and Disorders of the Hepatobiliary System and Pancreas — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 2,488 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2027

Index entries

Angiosarcoma, liver[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
Kupffer cell sarcoma[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
Sarcoma (of), Kupffer cell[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes

C22 — Malignant neoplasm of liver and intrahepatic bile ducts[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
C22.0 — Liver cell carcinoma[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
C22.1 — Intrahepatic bile duct carcinoma[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
C22.2 — Hepatoblastoma[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
C22.4 — Other sarcomas of liver[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
C22.7 — Other specified carcinomas of liver[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
C22.8 — Malignant neoplasm of liver, primary, unspecified as to type[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
C22.9 — Malignant neoplasm of liver, not specified as primary or secondary[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026

Change history

FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data: CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data: CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data: CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Risk adjustment Official source data: 2026 Mid-Year Final ICD-10 Mappings + Model Software (cms.gov/files/zip/2026-midyear-final-icd-10-mappings.zip, 2026-midyear-final-model-software.zip) — CMS-HCC V28, PY2026 mid-year final release Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data: CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship: Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation: Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "C22.3 — Angiosarcoma of liver." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/c22.3-angiosarcoma-of-liver

Change history

FY2016 — October 1, 2015
In the code set at ICD-10-CM adoption
Angiosarcoma of liver

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027, and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to C22.3 in its code family, with their registry titles.

View all codes in the C22 family

C22.3 ICD-10-CM Code: Angiosarcoma of liver

Coding at a Glance

Inpatient Payment Groups (MS-DRG)

Risk Adjustment (CMS-HCC)

Coding instructions

Inclusion Terms

Excludes1 — Not Coded Here

Excludes2 — Not Included Here

Use Additional Code

Coder workflow for C22.3

Before you code C22.3

Choose the right path

Documentation check

Official instructions as workflow

Coding decision scenarios

Code Overview

Indexed Clinical Terms (3)

Don’t confuse C22.3 with…

Decision Points

Verify Before Coding

Relationships & Classification

MS-DRG Grouper Relationships (FY2027)

Related Codes

Same clinical process (MS-DRG)

Same CMS-HCC risk category (V28)

Related risk categories

Same clinical category (CCSR)

Same Index main term, other category

Lab tests where this diagnosis supports Medicare coverage (NCD)

Contextual Map

Hierarchy

Clinical classification (CCSR)

Risk adjustment (CMS-HCC)

MS-DRG Grouper

MDC crossing

Index entries

Nearest codes

Change history

Sources for this page

Cite this page

Change history

Nearest Codes in This Family