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ICD-10/C22.0

C22.0 ICD-10-CM Code: Liver cell carcinoma

C22.0 is the authoritative medical code for Liver cell carcinoma. This classification is used in medical billing and clinical recording to specify the clinical criteria for liver cell carcinoma (ICD-10-CM C22.0), ensuring healthcare documentation aligns with current federal coding standards.

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0 (FY2026), Appendix B.

  • MS-DRG 435 — MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH MCC (MDC 07)
  • MS-DRG 436 — MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH CC (MDC 07)
  • MS-DRG 437 — MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITHOUT CC/MCC (MDC 07)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Code Set: Valid FY2026 and FY2027. FY2026 took effect October 1, 2025.

Official Registry Overview & Definition

Liver cell carcinoma is a billable ICD-10-CM diagnosis code (C22.0). Inclusion terms: Hepatocellular carcinoma; Hepatoma. Excludes1 (not coded here): malignant neoplasm of biliary tract NOS (C24.9); secondary malignant neoplasm of liver and intrahepatic bile duct (C78.7); Kaposi's sarcoma of gastrointestinal sites (C46.4). Excludes2 (not included here): gastrointestinal stromal tumors (C49.A-). Use additional code: code to identify:; alcohol abuse and dependence (F10.-); hepatitis B (B16.-, B18.0-B18.1); hepatitis C (B17.1-, B18.2).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for C22.0 in the official ICD-10-CM tabular list.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Hepatocellular carcinoma
  • Hepatoma

Excludes1 — Not Coded Here

Conditions that can never be reported with this code; the two are mutually exclusive.

  • malignant neoplasm of biliary tract NOS (C24.9)
  • secondary malignant neoplasm of liver and intrahepatic bile duct (C78.7)
  • Kaposi's sarcoma of gastrointestinal sites (C46.4)

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

  • gastrointestinal stromal tumors (C49.A-)

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code to identify:
  • alcohol abuse and dependence (F10.-)
  • hepatitis B (B16.-, B18.0-B18.1)
  • hepatitis C (B17.1-, B18.2)

Frequently Asked Questions (FAQ) & Clinical Guidance

What can't be coded together with C22.0?

Per official ICD-10-CM Excludes1 instructions, C22.0 must not be reported together with: malignant neoplasm of biliary tract NOS (C24.9); secondary malignant neoplasm of liver and intrahepatic bile duct (C78.7); Kaposi's sarcoma of gastrointestinal sites (C46.4).

Can C22.0 be reported alongside related conditions?

Per official ICD-10-CM Excludes2 instructions, C22.0 and the following are not considered part of each other and may both be reported when both conditions are present: gastrointestinal stromal tumors (C49.A-).

Is an additional code needed with C22.0?

Use additional code(s) to specify: code to identify:; alcohol abuse and dependence (F10.-); hepatitis B (B16.-, B18.0-B18.1); hepatitis C (B17.1-, B18.2).

What conditions are included under C22.0?

Liver cell carcinoma includes: Hepatocellular carcinoma; Hepatoma.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to C22.0 in its code family, with their registry titles.

  • C22 — Malignant neoplasm of liver and intrahepatic bile ducts
  • C22.1 — Intrahepatic bile duct carcinoma
  • C22.2 — Hepatoblastoma
  • C22.3 — Angiosarcoma of liver
  • C22.4 — Other sarcomas of liver
  • C22.7 — Other specified carcinomas of liver
  • C22.8 — Malignant neoplasm of liver, primary, unspecified as to type
  • C22.9 — Malignant neoplasm of liver, not specified as primary or secondary

View all codes in the C22 family

Indexed Clinical Terms (16)

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.

  • Cancer, hepatocellular
  • Carcinoma (malignant), bile duct, with hepatocellular, mixed
  • Carcinoma (malignant), hepatic cell
  • Carcinoma (malignant), hepatocellular
  • Carcinoma (malignant), hepatocellular, fibrolamellar
  • Carcinoma (malignant), hepatocellular, with bile duct, mixed
  • Carcinoma (malignant), hepatocholangiolitic
  • Carcinoma (malignant), liver cell
  • Cholangiocarcinoma, with hepatocellular carcinoma, combined
  • Cholangiohepatoma
  • Embryoma, liver
  • Embryoma, malignant, liver
  • Hepatocarcinoma
  • Hepatocholangiocarcinoma
  • Hepatoma (malignant)
  • Hepatoma (malignant), embryonal

Neoplasm Table Sites (1)

Anatomical sites from the official ICD-10-CM Table of Neoplasms that map to this code, with the matching behavior column.

  • Neoplasm, neoplastic, hepatoma — Malignant, Primary