D75.83 ICD-10-CM Code: Thrombocytosis

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for D75.83 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on D75.83 itself; “inherited from” names the category or block whose note applies here.

Coder workflow for D75.83

MedCoder structured workflow — derived from this code’s own official record

Before you code D75.83

1. D75.83 is not reportable as written. Select the more specific code beneath it that the documentation supports. Codes are reported to the highest level of specificity the classification provides (Guidelines I.B.2).

   ReviewD75.838, D75.839

   See the relationships section · Guide: How to choose an ICD-10-CM code →

Choose the right path

1. Does the documentation support one of the more specific codes beneath D75.83?
   Yes → Select that code and continue the checks below on its own page.
   No → D75.83 cannot be reported as written; query for the specificity its subcategory needs.

   ReviewD75.838, D75.839

Consider D75.83. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement

Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

Official instructions as workflow

• Excludes2 — not part of D75.83(7 notes)

  Coding workflow: The conditions named in this note are not included in D75.83. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

  CompareD47.3, L04, I88.1, R59, D89.2, I88.9

  See the official tabular notes · Guidelines I.A.12.b

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Don’t confuse D75.83 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of D75.83 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

• D47.3— Excludes2 relationship (Informational)

  Distinct conditions — both may be reported.

  A distinct condition — both may be reported when both are documented.

  What moves you there: Documentation of essential thrombocythemia adds D47.3; it is not part of this code and both may be reported when both are documented.

  Full comparison: D75.83 vs D47.3 →

• L04— Excludes2 relationship (Informational)

  Distinct conditions — both may be reported.

  A distinct condition — both may be reported when both are documented.

  What moves you there: Documentation of acute lymphadenitis adds L04; it is not part of this code and both may be reported when both are documented.

  Full comparison: D75.83 vs L04 →

• I88.1— Excludes2 relationship (Informational)

  Distinct conditions — both may be reported.

  A distinct condition — both may be reported when both are documented.

  What moves you there: Documentation of chronic lymphadenitis adds I88.1; it is not part of this code and both may be reported when both are documented.

  Full comparison: D75.83 vs I88.1 →

• R59— Excludes2 relationship (Informational)

  Distinct conditions — both may be reported.

  A distinct condition — both may be reported when both are documented.

  What moves you there: Documentation of enlarged lymph nodes adds R59; it is not part of this code and both may be reported when both are documented.

  Full comparison: D75.83 vs R59 →

• D89.2— Excludes2 relationship (Informational)

  Distinct conditions — both may be reported.

  A distinct condition — both may be reported when both are documented.

  What moves you there: Documentation of hypergammaglobulinemia NOS adds D89.2; it is not part of this code and both may be reported when both are documented.

  Full comparison: D75.83 vs D89.2 →

• I88.9— Excludes2 relationship (Informational)

  Distinct conditions — both may be reported.

  A distinct condition — both may be reported when both are documented.

  What moves you there: Documentation of lymphadenitis NOS adds I88.9; it is not part of this code and both may be reported when both are documented.

  Full comparison: D75.83 vs I88.9 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Verify Before Coding

• Not billable as written — a more specific code is required: D75.838, D75.839.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name D75.83 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 21 Code First instructions: T36 — Poisoning by, adverse effect of and underdosing of systemic antibiotics (via D75.-), T36-T39 — Antibiotics & Anti-infectives (T36-T39) (via D75.-), T36-T50 — Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances (T36-T50) (via D75.-), T37 — Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics (via D75.-), T38 — Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified (via D75.-), T39 — Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics (via D75.-), T40 — Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens] (via D75.-), T40-T41 — Analgesics & Antipyretics (T40-T41) (via D75.-), T41 — Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gases (via D75.-), T42 — Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs (via D75.-), T42-T43 — Anticonvulsants & Psychotropics (T42-T43) (via D75.-), T43 — Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified (via D75.-), T44 — Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system (via D75.-), T44-T46 — Cardiovascular & Gastrointestinal (T44-T46) (via D75.-), T45 — Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified (via D75.-), T46 — Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system (via D75.-), T47 — Poisoning by, adverse effect of and underdosing of agents primarily affecting the gastrointestinal system (via D75.-), T47-T50 — Hormones & Systemic Agents (T47-T50) (via D75.-), T48 — Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory system (via D75.-), T49 — Poisoning by, adverse effect of and underdosing of topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinorlaryngological and dental drugs (via D75.-), +1 more.

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

Contextual Map

Every relationship of D75.83 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run D75.83 with these 9 related codes in Claim Check

Hierarchy

• D50-D89 — Chapter 3: Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) (D50-D89)[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026

Excludes2

• D47.3 — Essential (hemorrhagic) thrombocythemia[Excludes2]: “essential thrombocythemia (D47.3)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Referenced by Code First instructions (21)

• T36 — Poisoning by, adverse effect of and underdosing of systemic antibiotics[Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T36-T39 — Antibiotics & Anti-infectives (T36-T39)[Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T36-T50 — Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances (T36-T50)[Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T37 — Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics[Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T38 — Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified[Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T39 — Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics[Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T40 — Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens][Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T40-T41 — Analgesics & Antipyretics (T40-T41)[Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• and 13 more

Nearest codes (16)

• D75 — Other and unspecified diseases of blood and blood-forming organs[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• D75.0 — Familial erythrocytosis[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• D75.1 — Secondary polycythemia[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• D75.8 — Other specified diseases of blood and blood-forming organs[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• D75.81 — Myelofibrosis[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• D75.82 — Heparin induced thrombocytopenia (HIT)[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• D75.821 — Non-immune heparin-induced thrombocytopenia[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• D75.822 — Immune-mediated heparin-induced thrombocytopenia[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• and 8 more

Change history

• FY2022 — Added to the code set[Change history]— CMS release files (code change ledger) · icd10cm-fy2022

Common coding questions

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data

CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page

Claim edits Official source data

CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page

Change history and date-of-service validity Official source data

CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page

Comparisons, relationships and the contextual map MedCoder structured relationship

Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears

Summary and FAQ answers MedCoder explanation

Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Nearest Codes in This Family

Official ICD-10-CM classifications closest to D75.83 in its code family, with their registry titles.

• D75.82 — Heparin induced thrombocytopenia (HIT)
• D75.821 — Non-immune heparin-induced thrombocytopenia
• D75.822 — Immune-mediated heparin-induced thrombocytopenia
• D75.828 — Other heparin-induced thrombocytopenia syndrome
• D75.829 — Heparin-induced thrombocytopenia, unspecified
• D75.838 — Other thrombocytosis
• D75.839 — Thrombocytosis, unspecified
• D75.84 — Other platelet-activating anti-PF4 disorders
• D75.89 — Other specified diseases of blood and blood-forming organs
• D75.9 — Disease of blood and blood-forming organs, unspecified

View all codes in the D75 family