E88.02 ICD-10-CM Code: Plasminogen deficiency

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for E88.02 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on E88.02 itself; “inherited from” names the category or block whose note applies here.

Coder workflow for E88.02

MedCoder structured workflow — derived from this code’s own official record

Before you code E88.02

1. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with E88.02. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

   See the official tabular notes

Choose the right path

1. Does the documentation support a condition named in E88.02’s Excludes1 note?
   Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
   No → Continue.

   ReviewD47.2, D89.0, C88.00, C96.6, E34.5, E25.0

Consider E88.02. Then work the Use Additional Code note and review the Code Also note, and confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement

Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

The conditions the Use Additional Code note names

Reported with this code when documented; a conditional instruction (“if applicable”, “if known”) applies only when the record supports it.

Official instructions as workflow

• Excludes1 — check before selecting E88.02(9 notes)

  Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with E88.02: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

  CompareD47.2, D89.0, C88.00, C96.6, E34.5, E25.0

  See the official tabular notes · Guidelines I.A.12.a

• Excludes2 — not part of E88.02(2 notes)

  Coding workflow: The conditions named in this note are not included in E88.02. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

  CompareE78, Q79.6

  See the official tabular notes · Guidelines I.A.12.b

• Use Additional Code — after identifying E88.02(5 notes)

  Coding workflow: Check whether the documentation supports the additional code(s) the note names, and report them with E88.02 when it does. Where the instruction is conditional (“if applicable”, “if known”), it applies only when the record documents the condition.

  ReviewG91.4, H67, J99

  See the official tabular notes · Guidelines I.A.13

• Code Also — related condition(1 note)

  Coding workflow: Review the related condition when both are documented and the instruction applies. A Code Also note does not fix sequencing; the order follows the circumstances of the encounter.

  ReviewH10.51

  See the official tabular notes · Guidelines I.A.17

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Indexed Clinical Terms (3)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

• Deficiency, deficient, plasminogen (type 1) (type 2)
• Dysplasminogenemia
• Hypoplasminogenemia

Don’t confuse E88.02 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of E88.02 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

• D47.2— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of monoclonal gammopathy (of undetermined significance) moves the case to D47.2; the two are not reported together unless documented as unrelated.

  Full comparison: E88.02 vs D47.2 →

• D89.0— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of polyclonal hypergammaglobulinemia moves the case to D89.0; the two are not reported together unless documented as unrelated.

  Full comparison: E88.02 vs D89.0 →

• C88.00— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of Waldenström macroglobulinemia moves the case to C88.00; the two are not reported together unless documented as unrelated.

  Full comparison: E88.02 vs C88.00 →

• C96.6— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of histiocytosis X (chronic) moves the case to C96.6; the two are not reported together unless documented as unrelated.

  Full comparison: E88.02 vs C96.6 →

• E34.5— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of androgen insensitivity syndrome moves the case to E34.5; the two are not reported together unless documented as unrelated.

  Full comparison: E88.02 vs E34.5 →

• E25.0— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of congenital adrenal hyperplasia moves the case to E25.0; the two are not reported together unless documented as unrelated.

  Full comparison: E88.02 vs E25.0 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Decision Points

The directives on this code's own record, as a pre-claim checklist.

1. 5 Use Additional Code instructions — report the named additional code(s) when the documentation supports them. See the Use Additional Code notes
2. 1 Code Also note — a second code may apply; the guidelines leave its sequencing to the circumstances of the encounter. See the Code Also notes
3. 9 Excludes1 entries — codes named there are generally not reported together with this code (Guidelines I.A.12.a). See the Excludes1 notes
4. 2 Excludes2 entries — those conditions are not part of this code and may be reported additionally when documented. See the Excludes2 notes

Checklist rows are derived from this code's own official directives; the wording of each check is MedCoder editorial. The official notes themselves are in the sections each row links to.

Verify Before Coding

• CC as a secondary diagnosis (FY2026). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name E88.02 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 2 Excludes1 notes across 2 chapters: P59 — Neonatal jaundice from other and unspecified causes (via E88.-), R77 — Other abnormalities of plasma proteins (via E88.0.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 4 Excludes2 notes across 2 chapters: G11 — Hereditary ataxia (via E88.-), G71 — Primary disorders of muscles (via E88.-), N25.0 — Renal osteodystrophy (via E88.-), N25.81 — Secondary hyperparathyroidism of renal origin (via E88.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

Referenced by 5 Code First instructions across 4 chapters: G63 — Polyneuropathy in diseases classified elsewhere (via E88.-), G91.4 — Hydrocephalus in diseases classified elsewhere, H42 — Glaucoma in diseases classified elsewhere (via E88.-), H67 — Otitis media in diseases classified elsewhere, J99 — Respiratory disorders in diseases classified elsewhere.

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

Referenced by 1 Code Also instruction: H10.51 — Ligneous conjunctivitis.

These codes suggest coding this condition alongside when both are present.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 136 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 8 MS-DRGs: DRG 826 (MDC 17), DRG 827 (MDC 17), DRG 828 (MDC 17), DRG 829 (MDC 17), DRG 830 (MDC 17), DRG 843 (MDC 17), DRG 844 (MDC 17), DRG 845 (MDC 17).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):END016 — Other specified and unspecified nutritional and metabolic disorders (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

E78.1 — Pure hyperglyceridemia, E78.2 — Mixed hyperlipidemia, E78.3 — Hyperchylomicronemia, E78.41 — Elevated Lipoprotein(a), E78.49 — Other hyperlipidemia, E78.5 — Hyperlipidemia, unspecified, E78.6 — Lipoprotein deficiency, E78.70 — Disorder of bile acid and cholesterol metabolism, unspecified, E78.79 — Other disorders of bile acid and cholesterol metabolism, E78.81 — Lipoid dermatoarthritis, E78.89 — Other lipoprotein metabolism disorders, E78.9 — Disorder of lipoprotein metabolism, unspecified, E88.09 — Other disorders of plasma-protein metabolism, not elsewhere classified, E88.10 — Lipodystrophy, unspecified, E88.11 — Partial lipodystrophy, E88.12 — Generalized lipodystrophy, E88.13 — Localized lipodystrophy, E88.14 — HIV-associated lipodystrophy, E88.19 — Other lipodystrophy, not elsewhere classified, E88.2 — Lipomatosis, not elsewhere classified, +115 more

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Other specified and unspecified nutritional and metabolic disorders).

E85.1 — Neuropathic heredofamilial amyloidosis, E85.2 — Heredofamilial amyloidosis, unspecified, E85.3 — Secondary systemic amyloidosis, E85.4 — Organ-limited amyloidosis, E85.8 — Other amyloidosis, E85.81 — Light chain (AL) amyloidosis, E85.82 — Wild-type transthyretin-related (ATTR) amyloidosis, E85.89 — Other amyloidosis, E85.9 — Amyloidosis, unspecified, E88.01 — Alpha-1-antitrypsin deficiency, E88.09 — Other disorders of plasma-protein metabolism, not elsewhere classified, E88.1 — Lipodystrophy, not elsewhere classified, E88.10 — Lipodystrophy, unspecified, E88.11 — Partial lipodystrophy, E88.12 — Generalized lipodystrophy, E88.13 — Localized lipodystrophy, E88.14 — HIV-associated lipodystrophy, E88.19 — Other lipodystrophy, not elsewhere classified, E88.2 — Lipomatosis, not elsewhere classified, E88.3 — Tumor lysis syndrome, +258 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Deficiency, deficient”; these codes share that main term but sit in a different category of the Tabular List.

E83.01 — Wilson's disease (ceruloplasmin), E83.32 — Hereditary vitamin D-dependent rickets (type 1) (type 2) (vitamin NOS, D, 25-hydroxylase), E83.39 — Other disorders of phosphorus metabolism (acid phosphatase), E83.821 — ENPP1 deficiency causing generalized arterial calcification of infancy (ENPP1, causing, generalized arterial calcification of infancy), E83.822 — ENPP1 deficiency causing autosomal recessive hypophosphatemic rickets type 2 (ENPP1, causing, autosomal recessive hypophosphatemic rickets type 2), E83.823 — ABCC6 deficiency causing generalized arterial calcification of infancy (ABCC6, causing generalized arterial calcification of infancy), E83.824 — ABCC6 deficiency causing pseudoxanthoma elasticum (ABCC6, pseudoxanthoma elasticum), E83.825 — CD73 deficiency causing arterial calcification (CD73 deficiency causing arterial calcification), E87.1 — Hypo-osmolality and hyponatremia (salt), E87.6 — Hypokalemia (kalium), F09 — Unspecified mental disorder due to known physiological condition (cognitive), F60.2 — Antisocial personality disorder (moral), F98.8 — Other specified behavioral and emotional disorders with onset usually occurring in childhood and adolescence (attention), G96.89 — Other specified disorders of central nervous system (central nervous system), H53.50 — Unspecified color vision deficiencies (color vision), H53.51 — Achromatopsia (color vision, achromatopsia), H53.52 — Acquired color vision deficiency (color vision, acquired), H53.53 — Deuteranomaly (color vision, deuteranomaly), H53.54 — Protanomaly (color vision, protanomaly), H53.55 — Tritanomaly (color vision, tritanomaly), +171 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

HbA1c Test (Glycated Hemoglobin), Alpha-Fetoprotein (AFP) Test, Blood Glucose Test, Gamma-glutamyl Transferase (GGT) Test, Iron Panel, Lipid Panel, Partial Thromboplastin Time (PTT) Test, Prothrombin Time Test and INR (PT/INR), Thyroid Stimulating Hormone (TSH)

Contextual Map

Every relationship of E88.02 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run E88.02 with these 12 related codes in Claim Check

Hierarchy

• E00-E89 — Chapter 4: Endocrine, Nutritional and Metabolic Diseases (E00-E89) (E00-E89)[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• E70-E88 — Metabolic disorders[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026

Use Additional Code

• G91.4 — Hydrocephalus in diseases classified elsewhere[Use Additional Code]: “hydrocephalus (G91.4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• H67 — Otitis media in diseases classified elsewhere[Use Additional Code]: “otitis media (H67.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• J99 — Respiratory disorders in diseases classified elsewhere[Use Additional Code]: “respiratory disorder related to plasminogen deficiency (J99)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Code Also

• H10.51 — Ligneous conjunctivitis[Code Also]: “, if applicable, ligneous conjunctivitis (H10.51-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Referenced by Excludes1 notes

• P59 — Neonatal jaundice from other and unspecified causes[Excludes1](via E88.-): “jaundice due to inborn errors of metabolism (E70-E88)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• R77 — Other abnormalities of plasma proteins[Excludes1](via E88.0.-): “disorders of plasma-protein metabolism (E88.0-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Referenced by Excludes2 notes

• G11 — Hereditary ataxia[Excludes2](via E88.-): “metabolic disorders (E70-E88)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• G71 — Primary disorders of muscles[Excludes2](via E88.-): “metabolic disorders (E70-E88)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• N25.0 — Renal osteodystrophy[Excludes2](via E88.-): “metabolic disorders classifiable to E70-E88”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• N25.81 — Secondary hyperparathyroidism of renal origin[Excludes2](via E88.-): “metabolic disorders classifiable to E70-E88”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Referenced by Code First instructions

• G63 — Polyneuropathy in diseases classified elsewhere[Code First](via E88.-): “metabolic diseases (E70-E88)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• G91.4 — Hydrocephalus in diseases classified elsewhere[Code First]: “plasminogen deficiency (E88.02)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• H42 — Glaucoma in diseases classified elsewhere[Code First](via E88.-): “specified metabolic disorder (E70-E88)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• H67 — Otitis media in diseases classified elsewhere[Code First]: “plasminogen deficiency (E88.02)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• J99 — Respiratory disorders in diseases classified elsewhere[Code First]: “plasminogen deficiency (E88.02)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Referenced by Code Also instructions

• H10.51 — Ligneous conjunctivitis[Code Also]: “plasminogen deficiency (E88.02)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Clinical classification (CCSR)

• END016 — Other specified and unspecified nutritional and metabolic disorders[CCSR]— AHRQ CCSR for ICD-10-CM Diagnoses (HCUP)

MS-DRG Grouper

• CC — Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (CC).”— CMS MS-DRG Definitions Manual (Appendix C) · FY2026
• DRG 826 — MYELOPROLIFERATIVE DISORDERS OR POORLY DIFFERENTIATED NEOPLASMS WITH MAJOR O.R. PROCEDURES WITH MCC[MS-DRG]: “MYELOPROLIFERATIVE DISORDERS OR POORLY DIFFERENTIATED NEOPLASMS WITH MAJOR O.R. PROCEDURES WITH MCC (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 827 — MYELOPROLIFERATIVE DISORDERS OR POORLY DIFFERENTIATED NEOPLASMS WITH MAJOR O.R. PROCEDURES WITH CC[MS-DRG]: “MYELOPROLIFERATIVE DISORDERS OR POORLY DIFFERENTIATED NEOPLASMS WITH MAJOR O.R. PROCEDURES WITH CC (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 828 — MYELOPROLIFERATIVE DISORDERS OR POORLY DIFFERENTIATED NEOPLASMS WITH MAJOR O.R. PROCEDURES WITHOUT CC/MCC[MS-DRG]: “MYELOPROLIFERATIVE DISORDERS OR POORLY DIFFERENTIATED NEOPLASMS WITH MAJOR O.R. PROCEDURES WITHOUT CC/MCC (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 829 — MYELOPROLIFERATIVE DISORDERS OR POORLY DIFFERENTIATED NEOPLASMS WITH OTHER PROCEDURES WITH CC/MCC[MS-DRG]: “MYELOPROLIFERATIVE DISORDERS OR POORLY DIFFERENTIATED NEOPLASMS WITH OTHER PROCEDURES WITH CC/MCC (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 830 — MYELOPROLIFERATIVE DISORDERS OR POORLY DIFFERENTIATED NEOPLASMS WITH OTHER PROCEDURES WITHOUT CC/MCC[MS-DRG]: “MYELOPROLIFERATIVE DISORDERS OR POORLY DIFFERENTIATED NEOPLASMS WITH OTHER PROCEDURES WITHOUT CC/MCC (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 843 — OTHER MYELOPROLIFERATIVE DISORDERS OR POORLY DIFFERENTIATED NEOPLASTIC DIAGNOSES WITH MCC[MS-DRG]: “OTHER MYELOPROLIFERATIVE DISORDERS OR POORLY DIFFERENTIATED NEOPLASTIC DIAGNOSES WITH MCC (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 844 — OTHER MYELOPROLIFERATIVE DISORDERS OR POORLY DIFFERENTIATED NEOPLASTIC DIAGNOSES WITH CC[MS-DRG]: “OTHER MYELOPROLIFERATIVE DISORDERS OR POORLY DIFFERENTIATED NEOPLASTIC DIAGNOSES WITH CC (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• and 1 more

MDC crossing

• MDC 17 — Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms[MDC crossing]: “Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 4,730 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

• Deficiency, deficient, plasminogen (type 1) (type 2)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Dysplasminogenemia[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Hypoplasminogenemia[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes (29)

• E88 — Other and unspecified metabolic disorders[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• E88.0 — Disorders of plasma-protein metabolism, not elsewhere classified[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• E88.01 — Alpha-1-antitrypsin deficiency[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• E88.09 — Other disorders of plasma-protein metabolism, not elsewhere classified[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• E88.1 — Lipodystrophy, not elsewhere classified[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• E88.10 — Lipodystrophy, unspecified[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• E88.11 — Partial lipodystrophy[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• E88.12 — Generalized lipodystrophy[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• and 21 more

Change history

• FY2019 — Added to the code set[Change history]— CMS release files (code change ledger) · icd10cm-fy2019

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data

CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page

Claim edits Official source data

CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page

Inpatient payment groups Official source data

CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page

Change history and date-of-service validity Official source data

CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page

Comparisons, relationships and the contextual map MedCoder structured relationship

Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears

Summary and FAQ answers MedCoder explanation

Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Nearest Codes in This Family

Official ICD-10-CM classifications closest to E88.02 in its code family, with their registry titles.

• E88 — Other and unspecified metabolic disorders
• E88.0 — Disorders of plasma-protein metabolism, not elsewhere classified
• E88.01 — Alpha-1-antitrypsin deficiency
• E88.09 — Other disorders of plasma-protein metabolism, not elsewhere classified
• E88.1 — Lipodystrophy, not elsewhere classified
• E88.10 — Lipodystrophy, unspecified
• E88.11 — Partial lipodystrophy
• E88.12 — Generalized lipodystrophy
• E88.13 — Localized lipodystrophy
• E88.14 — HIV-associated lipodystrophy

View all codes in the E88 family